The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid

被引：7

作者：

Kawashima, Hiroshi ^{[1
]}

Yoshizawa, Katsuhiko ^{[2
]}

机构：

[1] Suntory Global Innovat Ctr Ltd, Res Inst, Seika, Kyoto, Japan

[2] Mukogawa Womens Univ, Sch Food Sci & Nutr, Dept Innovat Food Sci, Nishinomiya, Hyogo, Japan

来源：

LIPIDS IN HEALTH AND DISEASE | 2023年 / 22卷 / 01期

关键词：

Mead acid; Eicosatrienoic acid; n-9; Arachidonic acid; Essential fatty acid; Polyunsaturated fatty acid; LEUKOTRIENE B-4 SYNTHESIS; 5,8,11-EICOSATRIENOIC ACID; EICOSATRIENOIC ACID; ARACHIDONIC-ACID; DIETARY ENRICHMENT; ATOPIC-DERMATITIS; DEFECTIVE MUTANT; IN-VITRO; METABOLISM; DEFICIENCY;

D O I：

10.1186/s12944-023-01937-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygenase and cyclooxygenase. Recent pathological and epidemiological studies on MA raise the possibility of its effects on inflammation, cancer, dermatitis and cystic fibrosis, suggesting it is an endogenous multifunctional PUFA. This review summarizes the biosynthesis, presence, metabolism and physiological roles of MA and its relation to various diseases, as well as the significance of MA in PUFA metabolism.

引用

页数：10

共 50 条

[1] The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid
Hiroshi Kawashima
Katsuhiko Yoshizawa
Lipids in Health and Disease, 22
[2] Synthesis and Characterization of Novel n-9 Fatty Acid Conjugates Possessing Antineoplastic Properties
Khan, Azmat A.
Husain, Ahmad
Jabeen, Mumtaz
Mustafa, Jamal
Owais, Mohammad
LIPIDS, 2012, 47 (10) : 973 - 986
[3] UNIQUE FATTY-ACID COMPOSITION OF NORMAL CARTILAGE - DISCOVERY OF HIGH-LEVELS OF N-9 EICOSATRIENOIC ACID AND LOW-LEVELS OF N-6 POLYUNSATURATED FATTY-ACIDS
ADKISSON, HD
RISENER, FS
ZARRINKAR, PP
WALLA, MD
CHRISTIE, WW
WUTHIER, RE
FASEB JOURNAL, 1991, 5 (03): : 344 - 353
[4] Effects of eicosatrienoic acid (20:3 n-9, Mead's acid) on some promalignant-related properties of three human cancer cell lines
Heyd, VL
Eynard, AR
PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2003, 71 (3-4) : 177 - 188
[5] Effect of dietary n-9 eicosatrienoic acid on the fatty acid composition of plasma lipid fractions and tissue phospholipids
Cleland, LG
Neumann, MA
Gibson, RA
Hamazaki, T
Akimoto, K
James, MJ
LIPIDS, 1996, 31 (08) : 829 - 837
[6] Effect of dietary (n-9) eicosatrienoic acid on rat leucocyte fatty acid composition and eicosanoid production.
James, M
Cleland, L
Gibson, R
Neumann, M
Hamazaki, T
Akimoto, K
FASEB JOURNAL, 1996, 10 (03): : 860 - 860
[7] 20:3 n-9 fatty acid (Mead's acid) down-regulates the expression of E-cadherin and desmoglein in cultured human squamous cell carcinoma (SCC)
Eynard, A
Jiang, W
Mansel, R
17TH INTERNATIONAL CANCER CONGRESS, VOL 1 AND 2, 1998, : 233 - 238
[8] (n-7) and (n-9) cis-monounsaturated fatty acid contents of 12 Brassica species
Barthet, Veronique J.
PHYTOCHEMISTRY, 2008, 69 (02) : 411 - 417
[9] Synthesis of Lipophilic Guanine N-9 Derivatives: Membrane Anchoring of Nucleobases Tailored to Fatty Acid Vesicles
Wamberg, Michael C.
Pedersen, Pernille L.
Loffler, Philipp M. G.
Albertsen, Anders N.
Maurer, Sarah E.
Nielsen, Kent A.
Monnard, Pierre-Alain
BIOCONJUGATE CHEMISTRY, 2017, 28 (07) : 1893 - 1905
[10] The Myristic Acid:Docosahexaenoic Acid Ratio Versus the n-6 Polyunsaturated Fatty Acid:n-3 Polyunsaturated Fatty Acid Ratio as Nonalcoholic Fatty Liver Disease Biomarkers
Antunes, Marina Masetto
Godoy, Guilherme
Curi, Rui
Visentainer, Jesui Vergilio
Bazotte, Roberto Barbosa
METABOLIC SYNDROME AND RELATED DISORDERS, 2022, 20 (02) : 69 - 78

← 1 2 3 4 5 →