Stereotactic radiosurgery for tumors of the pineal region: A single-center experience

被引：1

作者：

Zeynal, Mete ^{[1
,4
]}

Karaaslan, Burak ^{[2
]}

Dagli, Ozlem ^{[3
]}

Borcek, Alp ^{[2
]}

Kurt, Goekhan ^{[2
]}

Kadioglu, Hakan Hadi ^{[1
]}

Emmez, Omer Hakan ^{[2
]}

机构：

[1] Ataturk Univ, Fac Med, Dept Neurosurg, Erzurum, Turkiye

[2] Gazi Univ, Fac Med, Dept Neurosurg, Ankara, Turkiye

[3] Gazi Univ, Fac Med, Dept Neurosurg, Gamma Knife Unit, Ankara, Turkiye

[4] Ataturk Univ, Ataturk Univ Res Hosp, Fac Med, Dept Neurosurg, TR-25040 Erzurum, Turkiye

来源：

MEDICINE | 2023年 / 102卷 / 27期

关键词：

germ cell tumors; pineal tumors; pineocytoma; radiosurgery; MANAGEMENT; DIAGNOSIS;

D O I：

10.1097/MD.0000000000034005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tumors of the pineal region (TPRs) are rare neoplasms that are surgically challenging to resect. Conventional treatment strategies are available, but gamma knife radiosurgery (GKRS) is an alternative approach. This study presents a single-center experience with GKRS performed for TPR with and without histopathological diagnoses. The cases of 25 patients with TPRs treated with GKRS were retrospectively analyzed. Thirteen of these 25 patients had histopathological confirmation, and 13 had elevated serum alpha-fetoprotein and beta-human chorionic gonadotropin levels. The 25 patients had a mean follow-up duration of 61 months. The total response rate to GKRS was 60%, and a 53.8% decrease in the alpha-fetoprotein and beta human chorionic gonadotropin levels was observed. The findings of this study indicate that GKRS is a safe procedure for TPRs, even in the event of insufficient histopathological findings. This treatment approach provides increased Karnofsky performance scores and an extended life expectancy.

引用

页数：4

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