Nickel-Catalyzed Direct Cross-Coupling of Unactivated Aryl Fluorides with Aryl Bromides

被引：23

作者：

Ren, Jing-Ao ^{[1
]}

Na, Jin-He ^{[1
]}

Gui, Chao ^{[1
]}

Miao, Chengping ^{[2
]}

Chu, Xue-Qiang ^{[1
]}

Ma, Mengtao ^{[3
]}

Xu, Hao ^{[1
]}

Zhou, Xiaocong ^{[1
,2
]}

Shen, Zhi-Liang ^{[1
]}

机构：

[1] Nanjing Tech Univ, Tech Inst Fluorochemistry TIF, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

[2] Jiaxing Univ, Coll Biol Chem Sci & Engn, 118 Jiahang Rd, Jiaxing 314001, Peoples R China

[3] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 29期

基金：

中国国家自然科学基金;

关键词：

POLYFLUOROALKYL KETONES; HALIDES; ACTIVATION;

D O I：

10.1021/acs.orglett.3c02000

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzeddirect cross-coupling of unactivated aryl fluorideswith aryl bromides is realized. The one-pot reaction, which avoidsthe use of preformed and sensitive organometallic reagents, proceedseffectively via C-F bond cleavage at room temperature in THFin the presence of the phosphine ligand and magnesium powder (withor without TMSCl) to produce the desired biaryls in modest to goodyields.

引用

页码：5525 / 5529

页数：5

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