An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery

被引：44

作者：

Zhou, Yan ^{[1
]}

Jia, Xiaoteng ^{[2
]}

Pang, Daxin ^{[3
]}

Jiang, Shan ^{[1
]}

Zhu, Meihua ^{[1
]}

Lu, Geyu ^{[2
,4
]}

Tian, Yaping ^{[5
]}

Wang, Caiyun ^{[6
]}

Chao, Danming ^{[1
]}

Wallace, Gordon ^{[6
]}

机构：

[1] Jilin Univ, Coll Chem, Changchun 130012, Peoples R China

[2] Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China

[3] Jilin Univ, Coll Anim Sci, Changchun 130062, Peoples R China

[4] Jilin Univ, Int Ctr Future Sci, Changchun 130012, Peoples R China

[5] Jilin Univ, Hosp 1, Dept Dermatol & Venerol, Changchun 130021, Peoples R China

[6] Univ Wollongong, Intelligent Polymer Res Inst, ARC Ctr Excellence Electromat Sci, AIIM Facil, North Wollongong, NSW, Australia

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

澳大利亚研究理事会; 中国国家自然科学基金;

关键词：

POLYMERS;

D O I：

10.1038/s41467-023-35990-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Wearable transdermal iontophoresis offers advantages for patient-comfort when deploying epidermal diseases treatments but current self-powered iontophoresis based on energy harvesters is limited in the support of efficient long-term operation therapeutic administration. Here, the authors propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. Wearable transdermal iontophoresis eliminating the need for external power sources offers advantages for patient-comfort when deploying epidermal diseases treatments. However, current self-powered iontophoresis based on energy harvesters is limited to support efficient therapeutic administration over the long-term operation, owing to the low and inconsistent energy supply. Here we propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This system decreases the system complexity and form factors by using viologen-based hydrogels as an integrated drug reservoir and cathode material, eliminating the conventional interface impedance between the electrode and drug reservoir. The redox-active polyelectrolyte hydrogel offers a high energy density of 3.57 mWh cm(-2), and an optimal bioelectronic interface with ultra-soft nature and low tissue-interface impedance. The delivery dosage can be readily manipulated by tuning the viologen hydrogel and the iontophoresis stimulation mode. This iontophoresis patch demonstrates an effective treatment of an imiquimod-induced psoriasis mouse. Considering the advantages of being a reliable and efficient energy supply, simplified configuration, and optimal electrical skin-device interface, this battery-powered iontophoresis may provide a new non-invasive treatment for chronic epidermal diseases.

引用

页数：12