Snail inhibits metastasis via regulation of E-cadherin and is associated with prognosis in colorectal cancer

被引:6
作者
Wang, Weimin [1 ,2 ]
Jin, Jun [1 ]
Zhou, Zhen [3 ]
Wang, Yunfan [1 ]
Min, Ke [1 ]
Zuo, Xin [1 ]
Jiang, Jiaping [1 ]
Zhou, Yan [1 ,2 ,6 ]
Shi, Jun [4 ,5 ]
机构
[1] Yangzhou Univ, Yixing Hosp, Med Coll, Dept Oncol, Yixing 214200, Jiangsu, Peoples R China
[2] Yangzhou Univ, Med Coll, Inst Combining Chinese Tradit & Western Med, Yangzhou 225001, Jiangsu, Peoples R China
[3] Nanjing Univ Chinese Med, Dept Chinese Med, Nanjing 210029, Jiangsu, Peoples R China
[4] Yangzhou Univ, Yixing Hosp, Med Coll, Dept Gen Surg, Yixing 214200, Jiangsu, Peoples R China
[5] Yangzhou Univ, Yixing Hosp, Med Coll, Dept Gen Surg, 75 Yixing Tongzhen Rd, Yixing 214200, Jiangsu, Peoples R China
[6] Yangzhou Univ, Yixing Hosp, Med Coll, Dept Oncol, 75 Yixing Tongzhen Rd, Yixing 214200, Jiangsu, Peoples R China
关键词
colorectal cancer; Snail; E-cadherin; prognosis; metastasis; CELL-ADHESION MOLECULE; ADULTS; YOUNG; EXPRESSION;
D O I
10.3892/ol.2023.13857
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The overall survival (OS) rate of patients with colorectal cancer (CRC) remains low due to the lack of clear prognostic markers. Therefore, the identification of valuable prognostic markers is urgently required. Snail and E-Cadherin (E-Cad) are important protein molecules in the EMT process and play a crucial role in tumor invasion and metastasis. The present study investigated the clinical significance of Snail and E-cad expression in CRC. Compared with those in adjacent tissue, the expression levels of Snail and E-cad were significantly increased and decreased, respectively, in CRC. Moreover, low Snail and high E-cad expression were associated with clinicopathological features and longer OS time. Furthermore, Snail and E-cad could predict the prognosis of patients with CRC. Reverse transcription-qPCR, Western blotting, Wound scratch assay, High content cell migration experiment, which showed that low Snail or high E-cad expression inhibited invasion and metastasis of CRC. In conclusion, Snail can promote CRC invasion and metastasis by regulating E-cad. Snail and E-cad expression constitute a novel prognostic marker for CRC, and the present study revealed a greater combined effect of Snail and E-cad as effective prognostic markers in CRC for the first time.
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页数:10
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