Mechanisms of Oxidative Stress in Metabolic Syndrome

被引：292

作者：

Masenga, Sepiso K. ^{[1
,2
]}

Kabwe, Lombe S. ^{[1
]}

Chakulya, Martin ^{[1
]}

Kirabo, Annet ^{[2
]}

机构：

[1] Mulungushi Univ, Sch Med & Hlth Sci, HAND Res Grp, Livingstone Campus,POB 60009, Livingstone 60009, Zambia

[2] Vanderbilt Univ, Med Ctr, Dept Med, Room 536,Robinson Res Bldg, Nashville, TN 37232 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 09期

基金：

美国国家卫生研究院;

关键词：

oxidative stress; inflammatory cytokines; metabolic syndrome; obesity; hypertension; insulin resistance; hyperglycemia; hyperlipidemia; cardiovascular disease; ENDOPLASMIC-RETICULUM STRESS; LOW-GRADE INFLAMMATION; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; INSULIN-RESISTANCE; GUT MICROBIOTA; SERINE/THREONINE PHOSPHORYLATION; MEDITERRANEAN DIET; DIABETES-MELLITUS; OBESITY;

D O I：

10.3390/ijms24097898

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.

引用

页数：28

共 236 条

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