Acenaphthoimidazolylidene-ligated chiral oxazoline palladacycles: synthesis, structure, and application in intramolecular a-arylation of amides towards 3,3'-disubstituted oxindoles

被引：5
|
作者：
Yang, Hanxiao [1 ]
Wang, Kun [1 ]
Fang, Weiwei [1 ]
机构：
[1] Nanjing Forestry Univ, Coll Chem Engn, 159 Longpan Rd, Nanjing 210037, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 05期
基金：
中国国家自然科学基金;
关键词：
bulky acenaphthoimidazolylidene; oxazoline palladacycle; intramolecular alpha-arylations; 3,3'-disubstituted oxindoles; CPMe; HETEROCYCLIC CARBENE-PALLADACYCLE; PALLADIUM-CATALYZED AMINATION; SUZUKI-MIYAURA; ALPHA-ARYLATION; ATMOSPHERIC-PRESSURE; ASYMMETRIC-SYNTHESIS; ARYL CHLORIDES; BORONIC ACIDS; EFFICIENT; PRECATALYSTS;
D O I：
10.1002/ajoc.202300120
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general catalytic protocol for the Pd-catalyzed intramolecular arylations of N-(2-halogenoaryl) amides in eco-friendly medium was successfully developed by using rationally designed acenaphthoimidazolylidene-ligated chiral oxazoline palladacycles. Under the optimal reaction condition, a broad scope of substrates with various functional groups were well tolerated, leading to desired 3,3'-disubstituted oxindoles in excellent yields (up to 98% yield).
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页数：5
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