Exploring Cefiderocol Resistance Mechanisms in Burkholderia pseudomallei

被引：7
作者：
Hall, Carina M. M. [1 ]
Somprasong, Nawarat [1 ]
Hagen, Johannah P. P. [1 ]
Nottingham, Roxanne [1 ]
Sahl, Jason W. W. [1 ,2 ]
Webb, Jessica R. R. [3 ,4 ]
Mayo, Mark [3 ]
Currie, Bart J. J. [3 ]
Podin, Yuwana [5 ]
Wagner, David M. M. [1 ,2 ]
Keim, Paul [1 ,2 ]
Schweizer, Herbert P. P. [1 ,2 ]
机构：
[1] No Arizona Univ, Pathogen & Microbiome Inst, Flagstaff, AZ 86011 USA
[2] No Arizona Univ, Dept Biol Sci, Flagstaff, AZ 86011 USA
[3] Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia
[4] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Australia
[5] Univ Malaysia Sarawak, Inst Hlth & Community Med, Sarawak, Malaysia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2023年 / 67卷 / 06期
关键词：
Burkholderia pseudomallei; cefiderocol; resistance; PSEUDOMONAS-AERUGINOSA; SUSCEPTIBILITY; CEFTAZIDIME; SEQUENCE;
D O I：
10.1128/aac.00171-23
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by beta-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by beta-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.
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页数：5
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