Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells

被引：44

作者：

Yang, Guoqiang ^{[1
,2
,3
]}

Fan, Xuehui ^{[4
,5
,6
]}

Liu, Yingchun ^{[7
]}

Jie, Pingping ^{[7
]}

Mazhar, Maryam ^{[8
,9
,10
]}

Liu, Yong ^{[7
]}

Dechsupa, Nathupakorn ^{[2
]}

Wang, Li ^{[1
,10
]}

机构：

[1] Southwest Med Univ, Tradit Chinese Med Hosp, Res Ctr Integrated Chinese & Western Med, Luzhou, Peoples R China

[2] Chiang Mai Univ, Fac Associated Med Sci, Dept Radiol Technol, Mol Imaging & Therapy Res Unit, Chiang Mai, Thailand

[3] Southwest Med Univ, Tradit Chinese Med Hosp, Acupuncture & Rehabil Dept, Luzhou, Peoples R China

[4] Southwest Med Univ, Minist Educ, Key Lab Med Electrophysiol, Luzhou, Peoples R China

[5] Southwest Med Univ, Inst Cardiovasc Res, Collaborat Innovat Ctr Prevent Cardiovasc Dis, Med Electrophysiol Key Lab Sichuan Prov, Luzhou, Peoples R China

[6] Heidelberg Univ, Univ Med Ctr Mannheim UMM, Med Fac Mannheim, Dept Med 1, Mannheim, Germany

[7] Southwest Med Univ, Tradit Chinese Med Hosp, Dept Magnet Resonance Imaging, Luzhou, Peoples R China

[8] Southwest Med Univ, Tradit Chinese Med Hosp, Natl Tradit Chinese Med Clin Res Base, Luzhou, Peoples R China

[9] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Drug Res Ctr, Luzhou, Peoples R China

[10] Southwest Med Univ, Inst Integrated Chinese & Western Med, Luzhou, Peoples R China

来源：

STEM CELL REVIEWS AND REPORTS | 2023年 / 19卷 / 05期

关键词：

Mesenchymal stem cells; Immunomodulation; Therapeutics; Engineered; Immune cells; MARROW STROMAL CELLS; VERSUS-HOST-DISEASE; HUMAN BONE-MARROW; UMBILICAL-CORD; T-CELLS; IFN-GAMMA; EXTRACELLULAR VESICLES; INTERFERON-GAMMA; PERIPHERAL-BLOOD; UP-REGULATION;

D O I：

10.1007/s12015-023-10539-9

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell therapy, owing to their multipotent nature and ability to display potent and varied functions in different diseases. The functions of MSCs, including native immunomodulation, high self-renewal characteristic, and secretory and trophic properties, can be employed to improve the immune-modulatory functions in diseases. MSCs impact most immune cells by directly contacting and/or secreting positive microenvironmental factors to influence them. Previous studies have reported that the immunomodulatory role of MSCs is basically dependent on their secretion ability from MSCs. This review discusses the immunomodulatory capabilities of MSCs and the promising strategies to successfully improve the potential utilization of MSCs in clinical research.

引用

页码：1214 / 1231

页数：18

共 191 条

[1] Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages [J].