Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma

被引：5
作者：
Wu, Yaohai [1 ]
Zhang, Shiqiang [1 ]
Chen, Chujie [1 ]
Pang, Jun [1 ,2 ]
机构：
[1] Sun Yat sen Univ, Affiliated Hosp 7, Kidney & Urol Ctr, Pelvic Floor Disorders Ctr,Dept Urol, Shenzhen, Peoples R China
[2] Sun Yat sen Univ, Affiliated Hosp 7, Pelvic Floor Disorders Ctr, Kidney & Urol Ctr,Dept Urol, 628 Zhenyuan Rd,Xinhu St, Shenzhen 518107, Peoples R China
来源：
CURRENT UROLOGY | 2023年 / 17卷 / 01期
关键词：
Dysregulation; m(6)A modification; Renal cell carcinoma; MESSENGER-RNA METHYLATION; NUCLEAR-RNA; M(6)A METHYLTRANSFERASE; TUMOR PROLIFERATION; CRYSTAL-STRUCTURES; MECLOFENAMIC ACID; RISK SIGNATURE; N-6-METHYLADENOSINE; TRANSLATION; PROMOTES;
D O I：
10.1097/CU9.0000000000000135
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Increasing evidence indicates that N-6-methyladenosine (m(6)A) methylation modification serves important functions in biological metabolism. Dysregulation of m(6)A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m(6)A regulator dysregulation on RCC tumorigenesis and development. However, no comprehensive review that integrates and analyzes the roles of m(6)A modification in RCC has been published to date. In this review, we focus on the dysregulation of m(6)A regulators as it relates to RCC tumorigenesis and development, as well as possible applications of m(6)A modification in RCC diagnosis and therapeutics.
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收藏
页码：45 / 51
页数：7
相关论文
共 112 条
[51]   5′ UTR m6A Promotes Cap-Independent Translation [J].
Meyer, Kate D. ;
Patil, Deepak P. ;
Zhou, Jun ;
Zinoviev, Alexandra ;
Skabkin, Maxim A. ;
Elemento, Olivier ;
Pestova, Tatyana V. ;
Qian, Shu-Bing ;
Jaffrey, Samie R. .
CELL, 2015, 163 (04) :999-1010
[52]   Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons [J].
Meyer, Kate D. ;
Saletore, Yogesh ;
Zumbo, Paul ;
Elemento, Olivier ;
Mason, Christopher E. ;
Jaffrey, Samie R. .
CELL, 2012, 149 (07) :1635-1646
[53]   IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner [J].
Mueller, Simon ;
Glass, Markus ;
Singh, Anurag K. ;
Haase, Jacob ;
Bley, Nadine ;
Fuchs, Tommy ;
Lederer, Marcell ;
Dahl, Andreas ;
Huang, Huilin ;
Chen, Jianjun ;
Posern, Guido ;
Huettelmaier, Stefan .
NUCLEIC ACIDS RESEARCH, 2019, 47 (01) :375-390
[54]   The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112 [J].
Nhan Van Tran ;
Ernst, Felix G. M. ;
Hawley, Ben R. ;
Zorbas, Christiane ;
Ulryck, Nathalie ;
Hackert, Philipp ;
Bohnsack, Katherine E. ;
Bohnsack, Markus T. ;
Jaffrey, Samie R. ;
Graille, Marc ;
Lafontaine, Denis L. J. .
NUCLEIC ACIDS RESEARCH, 2019, 47 (15) :7719-7733
[55]   Modifications and functional genomics of human transfer RNA [J].
Pan, Tao .
CELL RESEARCH, 2018, 28 (04) :395-404
[56]   m6A RNA methylation promotes XIST-mediated transcriptional repression [J].
Patil, Deepak P. ;
Chen, Chun-Kan ;
Pickering, Brian F. ;
Chow, Amy ;
Jackson, Constanza ;
Guttman, Mitchell ;
Jaffrey, Samie R. .
NATURE, 2016, 537 (7620) :369-+
[57]   The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention [J].
Pendleton, Kathryn E. ;
Chen, Beibei ;
Liu, Kuanqing ;
Hunter, Olga V. ;
Xie, Yang ;
Tu, Benjamin P. ;
Conrad, Nicholas K. .
CELL, 2017, 169 (05) :824-+
[58]   Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1 [J].
Peng, Shiming ;
Xiao, Wen ;
Ju, Dapeng ;
Sun, Baofa ;
Hou, Nannan ;
Liu, Qianlan ;
Wang, Yanli ;
Zhao, Haijiao ;
Gao, Chunchun ;
Zhang, Song ;
Cao, Ran ;
Li, Pengfei ;
Huang, Huanwei ;
Ma, Yongfen ;
Wang, Yankai ;
Lai, Weiyi ;
Ma, Zhixiong ;
Zhang, Wei ;
Huang, Song ;
Wang, Hailin ;
Zhang, Zhiyuan ;
Zhao, Liping ;
Cai, Tao ;
Zhao, Yong-Liang ;
Wang, Fengchao ;
Nie, Yongzhan ;
Zhi, Gang ;
Yang, Yun-Gui ;
Zhang, Eric Erquan ;
Huang, Niu .
SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (488)
[59]   Mouse Chromosome 2 [J].
Peters, J ;
Church, D ;
Zuberi, AR ;
Selley, R .
MAMMALIAN GENOME, 1999, 10 (10) :941-941
[60]   Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase [J].
Ping, Xiao-Li ;
Sun, Bao-Fa ;
Wang, Lu ;
Xiao, Wen ;
Yang, Xin ;
Wang, Wen-Jia ;
Adhikari, Samir ;
Shi, Yue ;
Lv, Ying ;
Chen, Yu-Sheng ;
Zhao, Xu ;
Li, Ang ;
Yang, Ying ;
Dahal, Ujwal ;
Lou, Xiao-Min ;
Liu, Xi ;
Huang, Jun ;
Yuan, Wei-Ping ;
Zhu, Xiao-Fan ;
Cheng, Tao ;
Zhao, Yong-Liang ;
Wang, Xinquan ;
Danielsen, Jannie M. Rendtlew ;
Liu, Feng ;
Yang, Yun-Gui .
CELL RESEARCH, 2014, 24 (02) :177-189
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