Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma

被引：5
作者：
Wu, Yaohai [1 ]
Zhang, Shiqiang [1 ]
Chen, Chujie [1 ]
Pang, Jun [1 ,2 ]
机构：
[1] Sun Yat sen Univ, Affiliated Hosp 7, Kidney & Urol Ctr, Pelvic Floor Disorders Ctr,Dept Urol, Shenzhen, Peoples R China
[2] Sun Yat sen Univ, Affiliated Hosp 7, Pelvic Floor Disorders Ctr, Kidney & Urol Ctr,Dept Urol, 628 Zhenyuan Rd,Xinhu St, Shenzhen 518107, Peoples R China
来源：
CURRENT UROLOGY | 2023年 / 17卷 / 01期
关键词：
Dysregulation; m(6)A modification; Renal cell carcinoma; MESSENGER-RNA METHYLATION; NUCLEAR-RNA; M(6)A METHYLTRANSFERASE; TUMOR PROLIFERATION; CRYSTAL-STRUCTURES; MECLOFENAMIC ACID; RISK SIGNATURE; N-6-METHYLADENOSINE; TRANSLATION; PROMOTES;
D O I：
10.1097/CU9.0000000000000135
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Increasing evidence indicates that N-6-methyladenosine (m(6)A) methylation modification serves important functions in biological metabolism. Dysregulation of m(6)A regulators is related to the progression of different malignancies, including renal cell carcinoma (RCC). Recent studies have reported preliminary findings on the influence of m(6)A regulator dysregulation on RCC tumorigenesis and development. However, no comprehensive review that integrates and analyzes the roles of m(6)A modification in RCC has been published to date. In this review, we focus on the dysregulation of m(6)A regulators as it relates to RCC tumorigenesis and development, as well as possible applications of m(6)A modification in RCC diagnosis and therapeutics.
引用
收藏
页码：45 / 51
页数：7
相关论文
共 112 条
  • [1] HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
    Alarcon, Claudio R.
    Goodarzi, Hani
    Lee, Hyeseung
    Liu, Xuhang
    Tavazoie, Saeed
    Tavazoie, Sohail F.
    [J]. CELL, 2015, 162 (06) : 1299 - 1308
  • [2] RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome
    Arguello, A. Emilia
    DeLiberto, Amanda N.
    Kleiner, Ralph E.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (48) : 17249 - 17252
  • [3] The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus
    Baquero-Perez, Belinda
    Antanaviciute, Agne
    Yonchev, Ivaylo D.
    Carr, Ian M.
    Wilson, Stuart A.
    Whitehouse, Adrian
    [J]. ELIFE, 2019, 8
  • [4] Treatment of renal cell carcinoma: Current status and future directions
    Barata, Pedro C.
    Rini, Brian I.
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (06) : 507 - 524
  • [5] N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing
    Bartosovic, Marek
    Molares, Helena Covelo
    Gregorova, Pavlina
    Hrossova, Dominika
    Kudla, Grzegorz
    Vanacova, Stepanka
    [J]. NUCLEIC ACIDS RESEARCH, 2017, 45 (19) : 11356 - 11370
  • [6] Bokar JA, 1997, RNA, V3, P1233
  • [7] Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA
    Brown, Jessica A.
    Kinzig, Charles G.
    DeGregorio, Suzanne J.
    Steitz, Joan A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (49) : 14013 - 14018
  • [8] METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing
    Chen, Hao
    Gu, Lei
    Orellana, Esteban A.
    Wang, Yuanyuan
    Guo, Jiaojiao
    Liu, Qi
    Wang, Longfei
    Shen, Zhangfei
    Wu, Hao
    Gregory, Richard I.
    Xing, Yi
    Shi, Yang
    [J]. CELL RESEARCH, 2020, 30 (06) : 544 - 547
  • [9] Identification of a m6A RNA methylation regulators-based signature for predicting the prognosis of clear cell renal carcinoma
    Chen, Jing
    Yu, Kun
    Zhong, Guansheng
    Shen, Wei
    [J]. CANCER CELL INTERNATIONAL, 2020, 20 (01)
  • [10] RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
    Chen, Mengnuo
    Wei, Lai
    Law, Cheuk-Ting
    Tsang, Felice Ho-Ching
    Shen, Jialing
    Cheng, Carol Lai-Hung
    Tsang, Long-Hin
    Ho, Daniel Wai-Hung
    Chiu, David Kung-Chun
    Lee, Joyce Man-Fong
    Wong, Carmen Chak-Lui
    Ng, Irene Oi-Lin
    Wong, Chun-Ming
    [J]. HEPATOLOGY, 2018, 67 (06) : 2254 - 2270
12345678910