Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction

被引：4

作者：

Streng, Koen W. ^{[1
]}

Hillege, Hans L. ^{[1
]}

ter Maaten, Jozine M. ^{[1
]}

van Veldhuisen, Dirk J. ^{[1
]}

Dickstein, Kenneth ^{[2
,3
]}

Samani, Nilesh J. ^{[4
,5
]}

Ng, Leong L. ^{[4
,5
]}

Metra, Marco ^{[6
]}

Filippatos, Gerasimos S. ^{[7
,8
]}

Ponikowski, Piotr ^{[9
,10
]}

Zannad, Faiez ^{[11
]}

Anker, Stefan D. ^{[12
,13
]}

van der Meer, Peter ^{[1
]}

Lang, Chim C.

Voors, Adriaan A. ^{[1
]}

Damman, Kevin ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[2] Univ Bergen, N-5007 Bergen, Norway

[3] Stavanger Univ Hosp, Stavanger, Norway

[4] Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester, England

[5] Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester LE3 9QP, England

[6] Univ Brescia, Inst Cardiol, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Brescia, Italy

[7] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Athens, Greece

[8] Univ Cyprus, Nicosia, Cyprus

[9] Wroclaw Med Univ, Dept Heart Dis, Wroclaw, Poland

[10] Mil Hosp, Cardiol Dept, Div Mol & Clin Med, Wroclaw DD1 9SY, Poland

[11] Univ Lorraine, CHRU Nancy, Ctr Invest Clin Plurithe Mat 1433, F CRIN INI CRCT,U1116,INSERM, Nancy, France

[12] Charite Univ Med Berlin, German Ctr Cardiovasc Res DZHK, CVK, Div Cardiol & Metab,Partner Site Berlin,Dept Cardi, Berlin, Germany

[13] Charite Univ Med Berlin, German Ctr Cardiovasc Res DZHK, Berlin Brandenburg Ctr Regenerat Therapies BCRT, Partner Site Berlin, Berlin, Germany

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2024年 / 17卷 / 01期

关键词：

Heart failure; Renal function; Urinary markers; Proximal tubule; RENAL DYSFUNCTION; PROXIMAL TUBULE; KIDNEY; DIAGNOSIS; PATHOPHYSIOLOGY; COMORBIDITIES; EPIDEMIOLOGY; PROGRESSION; IMPAIRMENT; VALIDATION;

D O I：

10.1007/s12265-023-10356-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundRecent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting different nephron segments in heart failure patients.MethodsIn 2070, in chronic heart failure patients, we measured several established and upcoming urinary markers reflecting different nephron segments.ResultsMean age was 70 +/- 12 years, 74% was male and 81% (n = 1677) had HFrEF. Mean estimated glomerular filtration rate (eGFR) was lower in patients with HFpEF (56 +/- 23 versus 63 +/- 23 ml/min/1.73 m(2), P = 0.001). Patients with HFpEF had significantly higher values of NGAL (58.1 [24.0-124.8] versus 28.1 [14.6-66.9] mu g/gCr, P < 0.001) and KIM-1 (2.28 [1.49-4.37] versus 1.79 [0.85-3.49] mu g/gCr, P = 0.001). These differences were more pronounced in patients with an eGFR > 60 ml/min/1.73m(2).ConclusionsHFpEF patients showed more evidence of tubular damage and/or dysfunction compared with HFrEF patients, in particular when glomerular function was preserved.

引用

页码：3 / 12

页数：10

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