Neuroserpin: A potential biomarker for early-onset severe preeclampsia

被引:3
作者
Perucci, Luiza Oliveira [1 ,2 ,8 ]
da Silva, Sirlaine Pio Gomes [2 ]
Bearzoti, Eduardo [3 ]
Pinto, Kelerson Mauro de Castro [2 ,4 ]
Alpoim, Patricia Nessralla [5 ]
Pinheiro, Melina de Barros [6 ]
Godoi, Lara Carvalho [7 ]
de Moraes, Lauro Angelo Goncalves [1 ]
de Sousa, Lirlandia Pires [5 ]
Dusse, Luci Maria Sant Ana [5 ]
Talvani, Andre [2 ,8 ]
机构
[1] Univ Fed Ouro Preto, Inst Exact & Biol Sci, Nucleus Res Biol Sci, Ouro Preto, MG, Brazil
[2] Univ Fed Ouro Preto, Inst Exact & Biol Sci, Lab Immunobiol & Inflammat, Ouro Preto, MG, Brazil
[3] Univ Fed Ouro Preto, Inst Exact & Biol Sci, Dept Stat, Ouro Preto, MG, Brazil
[4] Univ Fed Ouro Preto, Sch Phys Educ, Ouro Preto, MG, Brazil
[5] Fac Pharm, Dept Clin & Toxicol Anal, Belo Horizonte, MG, Brazil
[6] Univ Fed Sao Joao del Rei, Ctr Oeste Dona Lindu Campus, Divinopolis, MG, Brazil
[7] Univ Fed Minas Gerais, Tech Coll, Belo Horizonte, MG, Brazil
[8] Univ Fed Ouro Preto, Dept Biol Sci ICEB, Lab Inflammat Immunobiol, BR-35400000 Ouro Preto, MG, Brazil
关键词
Neuroserpin; IL-17A; IL-33; CXCL-16; Inflammation; Preeclampsia; CHEMOKINE LIGAND 16; NF-KAPPA-B; PREGNANT-WOMEN; CXC CHEMOKINE; DUAL FUNCTION; T-CELLS; CYTOKINE; IL-33; RECEPTOR; INFLAMMATION;
D O I
10.1016/j.imbio.2023.152339
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Preeclampsia is a hypertensive disease of pregnancy associated with intense inflammatory and pro-coagulant responses. Neuroserpin is a serine protease inhibitor that has been involved in neurological and immune pro-cesses and has not yet been investigated in preeclampsia. Herein, we evaluated neuroserpin levels in association with other inflammatory mediators (IL-17A, IL-33, and CXCL-16) during severe preeclampsia. The mediators' plasma levels were measured by immunoassays in 24 pregnant women with severe preeclampsia (early pre-eclampsia: N = 17, late preeclampsia: N = 7), 34 normotensive pregnant women, and 32 non-pregnant women. In general, pregnancy was associated with higher levels of neuroserpin, IL-17A, IL-33, and CXCL-16 than the non-pregnant state. However, this increase was attenuated in pregnancies complicated by severe preeclampsia. Although neuroserpin levels did not differ between normotensive pregnant women and pregnant women with severe preeclampsia, neuroserpin levels tended to be lower in early-onset than in late-onset severe preeclampsia. There were positive correlations between neuroserpin and IL-17A, neuroserpin and CXCL-16, and IL-17A and CXCL-16 levels in women with severe preeclampsia. In addition, although the risk for developing severe pre-eclampsia was higher in older women in this study, maternal age did not significantly influence the mediators' levels, nor their correlations in the preeclampsia group. In summary, our data suggest that neuroserpin might be a potential biomarker for early-onset severe preeclampsia and, that the imbalance among neuroserpin, IL-17A, IL-33, and CXCL-16 levels may be associated with the pathogenesis of preeclampsia, regardless of the maternal age.
引用
收藏
页数:9
相关论文
共 70 条
[31]   Coagulation and fibrinolytic system protein profiles in women with normal pregnancies and pregnancies complicated by hypertension [J].
Hale, Sarah A. ;
Sobel, Burton ;
Benvenuto, Anna ;
Schonberg, Adrienne ;
Badger, Gary J. ;
Bernstein, Ira M. .
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 2012, 2 (02) :152-157
[32]   Interleukin-33-cytokine of dual function or novel alarmin? [J].
Haraldsen, Guttorm ;
Balogh, Johanna ;
Pollheimer, Jurgen ;
Sponheim, Jon ;
Kuchler, Axel M. .
TRENDS IN IMMUNOLOGY, 2009, 30 (05) :227-233
[33]   The neurotoxicity of tissue plasminogen activator? [J].
Kaur, J ;
Zhao, ZG ;
Klein, GM ;
Lo, EH ;
Buchan, AM .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (09) :945-963
[34]   Physiological and pathological functions of neuroserpin: Regulation of cellular responses through multiple mechanisms [J].
Lee, Tet Woo ;
Tsang, Vicky W. K. ;
Loef, Evert Jan ;
Birch, Nigel P. .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2017, 62 :152-159
[35]   CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5years follow-up [J].
Lekva, Tove ;
Michelsen, Annika E. ;
Aukrust, Pal ;
Roland, Marie Cecilie Paasche ;
Henriksen, Tore ;
Bollerslev, Jens ;
Ueland, Thor .
DIABETES & VASCULAR DISEASE RESEARCH, 2017, 14 (06) :525-533
[36]   Expression and significance of serum soluble fms-like tyrosine kinase 1 (sFlt-1), CXC chemokine ligand 16 (CXCL16), and lipocalin 2 (LCN-2) in pregnant women with preeclampsia [J].
Li, Lingling ;
Ling, Bo ;
Mei, Jie ;
Wang, Yuju ;
Zhang, Jian ;
Zhao, Xiaolan .
ANNALS OF PALLIATIVE MEDICINE, 2021, 10 (07) :7866-7871
[37]   Incidence and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and eclampsia at preterm and term gestation: a population-based study [J].
Lisonkova, Sarka ;
Bone, Jeffrey N. ;
Muraca, Giulia M. ;
Razaz, Neda ;
Wang, Li Qing ;
Sabr, Yasser ;
Boutin, Amelie ;
Mayer, Chantal ;
Joseph, K. S. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2021, 225 (05) :538.e1-538.e19
[38]   Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease [J].
Lisonkova, Sarka ;
Joseph, K. S. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2013, 209 (06) :544.e1-544.e12
[39]   Maternal Morbidity Associated With Early-Onset and Late-Onset Preeclampsia [J].
Lisonkova, Sarka ;
Sabr, Yasser ;
Mayer, Chantal ;
Young, Carmen ;
Skoll, Amanda ;
Joseph, K. S. .
OBSTETRICS AND GYNECOLOGY, 2014, 124 (04) :771-781
[40]   Structural insights into the interaction of IL-33 with its receptors [J].
Liu, Xi ;
Hammel, Michal ;
He, Yanfeng ;
Tainer, John A. ;
Jeng, U-Ser ;
Zhang, Linqi ;
Wang, Shuying ;
Wang, Xinquan .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (37) :14918-14923