Mechanical Characterization and Single-Cell Imaging of Bacterial Biofilms

被引：2
作者：
Moreau, Alexis [1 ]
Mukherjee, Sampriti [2 ]
Yan, Jing [1 ]
机构：
[1] Yale Univ, Quantitat Biol Inst, Dept Mol Cellular & Dev Biol, 260 Whitney Ave, New Haven, CT 06511 USA
[2] Univ Chicago, Dept Mol Genet & Cell Biol, 920 E 58th St,Suite 1106, Chicago, IL 60637 USA
来源：
ISRAEL JOURNAL OF CHEMISTRY | 2023年 / 63卷 / 5-6期
关键词：
Biofilms; biomechanics; microscopy; single-cell; VIBRIO-CHOLERAE; STAPHYLOCOCCUS-EPIDERMIDIS; EXOPOLYSACCHARIDE; POLYSACCHARIDE; ENTANGLEMENT; TOLERANCE; MATRIX; FLOW; PEL;
D O I：
10.1002/ijch.202200075
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Bacterial biofilms are structured clusters of bacterial cells embedded in a polymeric matrix and attached to a surface. The extracellular matrix protects the bacteria and allows them to survive in hostile environmental conditions. Biofilms can be both beneficial and harmful in nature, medicine and industry. Here, we summarize recent advances in understanding the mechanics of bacterial biofilms and high-resolution imaging techniques to visualize and reconstruct biofilms at single-cell level. A deeper understanding of biofilm architecture and mechanics will potentially lead to new treatment of biofilm-related infections and new material design enabled by biofilms.
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页数：7
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