Fatal mucormycosis and aspergillosis coinfection associated with haemophagocytic lymphohistiocytosis: A case report and literature review

被引：4
作者：
Loubet, Dorian [1 ]
Sarton, Benjamine [2 ,3 ]
Lelievre, Lucie [4 ]
Grouteau, Gaspard [4 ]
Iriart, Xavier [1 ,6 ]
Chauvin, Pamela [1 ]
Fillaux, Judith [1 ]
Valentin, Alexis [1 ,5 ]
Berry, Antoine [1 ,6 ]
Silva, Stein [2 ,3 ]
Bonneville, Fabrice [7 ]
Cassaing, Sophie [1 ,8 ]
Guemas, Emilie [1 ,6 ]
机构：
[1] CHU Toulouse, Dept Parasitol & Mycol, Toulouse, France
[2] Univ Hosp Purpan, Crit Care Unit, Toulouse, France
[3] Univ Paul Sabatier, INSERM, Unite Mixte Rech 1214, Toulouse Neuroimaging Ctr, Toulouse, France
[4] CHU Toulouse, Dept Infect & Trop Dis, Toulouse, France
[5] Univ Toulouse, PHARMA Dev, UMR 152 IRD, UPS, Toulouse, France
[6] Univ Toulouse, Inst Toulousain Malad Infect & Inflammatoires Inf, CNRS, UMR5051,INSERM,UMR1291,UPS, Toulouse, France
[7] Pierre Paul Riquet Purpan Univ Hosp, Neuroradiol Dept, Toulouse, France
[8] Univ P Sabatier, RESTORE Inst, UMR 1301, Inserm 5070,CNRS EFS, Toulouse, France
来源：
JOURNAL DE MYCOLOGIE MEDICALE | 2023年 / 33卷 / 01期
关键词：
Mucormycosis; Aspergillosis; Invasive fungal infection; Haemophagocytic lymphohistiocytosis; Varicella zoster virus; INFECTION; DIAGNOSIS;
D O I：
10.1016/j.mycmed.2022.101325
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Invasive mould infections are life-threatening and mainly occur in immunocompromised patients. Whereas aspergillosis is described during haemophagocytic lymphohistiocytosis (HLH), only a few cases of concomi-tant mucormycosis with HLH have been reported. Here, we present an uncommon coinfection of mucormy-cosis and aspergillosis associated with HLH probably due to a varicella zoster virus (VZV) viraemia which was unresponsive to triple antifungal therapy (liposomal amphotericin B combined with isavuconazole and caspofungin). A review of the cases of mucormycosis with HLH showed that this uncommon association was always lethal and underscored the relevance of screening for mould infections in patients with HLH.(c) 2022 The Authors. Published by Elsevier Masson SAS on behalf of SFMM. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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页数：5
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