A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations

被引：6

作者：

Elshibani, Fatma A. ^{[1
]}

Alamami, Abdullah D. ^{[2
]}

Mohammed, Hamdoon A. ^{[3
,4
]}

Rasheed, Rabab Ahmed ^{[5
]}

El Sabban, Radwa M. ^{[6
]}

Yehia, Mohamed A. ^{[7
]}

Abdel Mageed, Sherif S. ^{[8
]}

Majrashi, Taghreed A. ^{[9
]}

Elkaeed, Eslam B. ^{[10
]}

El Hassab, Mahmoud A. ^{[11
]}

Eldehna, Wagdy M. ^{[12
]}

El-Ashrey, Mohamed K. ^{[11
,13
]}

机构：

[1] Univ Benghazi, Fac Pharm, Dept Pharmacognosy, Benghazi, Libya

[2] Univ Benghazi, Fac Pharm, Dept Basic Med Sci, Benghazi, Libya

[3] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Qasim, Saudi Arabia

[4] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy & Med Plants, Cairo, Egypt

[5] King Salman Int Univ KSIU, Fac Med, Dept Med Histol & Cell Biol, South Sinai, Egypt

[6] October 6 Univ, Fac Med, Dept Anat, Giza, Egypt

[7] October 6 Univ, Fac Med, Dept Forens Med & Clin Toxicol, Giza, Egypt

[8] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Cairo, Egypt

[9] King Khalid Univ, Coll Pharm, Dept Pharmacognosy, Asir, Saudi Arabia

[10] AlMaarefa Univ, Coll Pharm, Dept Pharmaceut Sci, Riyadh, Saudi Arabia

[11] King Salman Int Univ KSIU, Fac Pharm, Dept Med Chem, South Sinai, Egypt

[12] Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Chem, Kafrelsheikh, Egypt

[13] Cairo Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo, Egypt

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2024年 / 39卷 / 01期

关键词：

Oxidative stress; immunohistochemistry; libyan strawberry; phytochemicals; molecular docking; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; IDENTIFICATION; EXTRACT; INHIBITION; QUERCETIN; CYTOKINES; DOCKING; ALPHA; IL-6;

D O I：

10.1080/14756366.2023.2293639

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Libyan Strawberry, Arbutus pavarii Pampan (ARB), is an endemic Jebel Akhdar plant used for traditional medicine. This study presents the antioxidant and hepatoprotective properties of ARB fruit-extract. ARB phytochemical analysis indicated the presence of 354.54 GAE and 36.2 RE of the phenolics and flavonoids. LC-MS analysis identified 35 compounds belonging to phenolic acids, procyanidins, and flavonoid glycosides. Gallic acid, procyanidin dimer B3, beta-type procyanidin trimer C, and quercetin-3-O-glucoside were the major constituents of the plant extract. ARB administration to paracetamol (PAR)-intoxicated rats reduced serum ALT, AST, bilirubin, hepatic tissue MDA and proinflammatory markers; TNF-alpha and IL-6 with an increase in tissue GSH level and SOD activity. Histological and immunohistochemical studies revealed that ARB restored the liver histology and significantly reduced the tissue expression of caspase 3, IL-1B, and NF-KB in PAR-induced liver damage. Docking analysis disclosed good binding affinities of some compounds with XO, COX-1, 5-LOX, and PI3K.

引用

页数：16

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