White adipocyte dysfunction and obesity-associated pathologies in humans (vol 25, pg 270, 2023)

被引：0
作者：
Hagberg, Carolina E.
Spalding, Kirsty L.
机构：
[1] Division of Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Stockholm
[2] Center for Molecular Medicine, Karolinska Institutet, Stockholm
[3] Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2024年 / 25卷 / 04期
基金：
瑞典研究理事会;
关键词：
D O I：
10.1038/s41580-024-00712-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The prevalence of obesity and associated chronic diseases continues to increase worldwide, negatively impacting on societies and economies. Whereas the association between excess body weight and increased risk for developing a multitude of diseases is well established, the initiating mechanisms by which weight gain impairs our metabolic health remain surprisingly contested. In order to better address the myriad of disease states associated with obesity, it is essential to understand adipose tissue dysfunction and develop strategies for reinforcing adipocyte health. In this Review we outline the diverse physiological functions and pathological roles of human white adipocytes, examining our current knowledge of why white adipocytes are vital for systemic metabolic control, yet poorly adapted to our current obesogenic environment. © Springer Nature Limited 2023. corrected publication 2024.
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收藏
页码：333 / 333
页数：1
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