Genomic Regions and Candidate Genes Associated with Milk Production Traits in Holstein and Its Crossbred Cattle: A Review

被引:11
|
作者
Bekele, R. [1 ,2 ]
Taye, M. [1 ]
Abebe, G. [1 ]
Meseret, S. [3 ]
机构
[1] Hawassa Univ, Coll Agr, Sch Anim & Range Sci, POB 5, Hawassa, Ethiopia
[2] Debre Berhan Univ, Coll Agr & Nat Resource Sci, Dept Anim Sci, POB 445, Debre Berhan, Ethiopia
[3] Int Livestock Res Inst ILRI, Livestock Genet, Addis Ababa, Ethiopia
关键词
SOMATIC-CELL SCORE;
D O I
10.1155/2023/8497453
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genome-wide association studies (GWAS) are a powerful tool for identifying genomic regions and causative genes associated with economically important traits in dairy cattle, particularly complex traits, such as milk production. This is possible due to advances in next-generation sequencing technology. This review summarized information on identified candidate genes and genomic regions associated with milk production traits in Holstein and its crossbreds from various regions of the world. Milk production traits are important in dairy cattle breeding programs because of their direct economic impact on the industry and their close relationship with nutritional requirements. GWAS has been used in a large number of studies to identify genomic regions and candidate genes associated with milk production traits in dairy cattle. Many genomic regions and candidate genes have already been identified in Holstein and its crossbreds. Genes and single nucleotide polymorphisms (SNPs) that significantly affect milk yield (MY) were found in all autosomal chromosomes except chromosomes 27 and 29. Half of the reported SNPs associated with fat yield and fat percentage were found on chromosome 14. However, a large number of significant SNPs for protein yield (PY) and protein percentage were found on chromosomes 1, 5, and 20. Approximately 155 SNPs with significant influence on multiple milk production traits have been identified. Several promising candidate genes, including diacylglycerol O-acyltransferase 1, plectin, Rho GTPase activating protein 39, protein phosphatase 1 regulatory subunit 16A, and sphingomyelin phosphodiesterase 5 were found to have pleiotropic effects on all five milk production traits. Thus, to improve milk production traits it is of practical relevance to focus on significant SNPs and pleiotropic genes frequently found to affect multiple milk production traits.
引用
收藏
页数:18
相关论文
共 50 条
  • [31] Comparison of genome-wide association and genomic prediction methods for milk production traits in Korean Holstein cattle
    Lee, SeokHyun
    Dang, ChangGwon
    Choy, Yunho
    Do, ChangHee
    Cho, Kwanghyun
    Kim, Jongjoo
    Kim, Yousam
    Lee, Jungjae
    ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 2019, 32 (07): : 913 - 921
  • [32] Uncovering the genetic basis of milk production traits in Mexican Holstein cattle based on individual markers and genomic windows
    Cortes-Hernandez, Jose G.
    Garcia-Ruiz, Adriana
    Penagaricano, Francisco
    Montaldo, Hugo H.
    Ruiz-Lopez, Felipe J.
    PLOS ONE, 2025, 20 (02):
  • [33] Genetic Characteristics of Five Microsatellite Markers Associated with Milk Production Traits in Crossbred Dairy Cattle of Kerala
    Thomas, Naicy
    Anilkumar, K.
    VETERINARY WORLD, 2008, 1 (08) : 245 - 247
  • [34] Research Progress on Genomic Regions and Candidate Genes Related to Milk Composition Traits of Dairy Goats Based on Functional Genomics: A Narrative Review
    Yang, Xu
    Li, Qing
    Wang, Yanyan
    Wang, Jianmin
    Hu, Jiaqing
    Ji, Zhibin
    Chao, Tianle
    GENES, 2024, 15 (10)
  • [35] Genomic Selection for Milk Production Traits in Xinjiang Brown Cattle
    Zhang, Menghua
    Luo, Hanpeng
    Xu, Lei
    Shi, Yuangang
    Zhou, Jinghang
    Wang, Dan
    Zhang, Xiaoxue
    Huang, Xixia
    Wang, Yachun
    ANIMALS, 2022, 12 (02):
  • [36] Genomic scans for selection signatures revealed candidate genes for adaptation and production traits in a variety of cattle breeds
    Saravanan, K. A.
    Panigrahi, Manjit
    Kumar, Harshit
    Parida, Subhashree
    Bhushan, Bharat
    Gaur, G. K.
    Dutt, Triveni
    Mishra, B. P.
    Singh, R. K.
    GENOMICS, 2021, 113 (03) : 955 - 963
  • [37] EFFECTS OF POLYMORPHIC MILK PROTEIN GENES ON MILK-YIELD AND COMPOSITION TRAITS IN HOLSTEIN CATTLE
    MAO, IL
    BUTTAZZONI, LG
    ALEANDRI, R
    ACTA AGRICULTURAE SCANDINAVICA SECTION A-ANIMAL SCIENCE, 1992, 42 (01): : 1 - 7
  • [38] Comparative genomic analysis uncovers candidate genes related with milk production and adaptive traits in goat breeds
    Ghanatsaman, Zeinab Amiri
    Mehrgardi, Ahmad Ayatolahi
    Nanaei, Hojjat Asadollahpour
    Esmailizadeh, Ali
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [39] Comparative genomic analysis uncovers candidate genes related with milk production and adaptive traits in goat breeds
    Zeinab Amiri Ghanatsaman
    Ahmad Ayatolahi Mehrgardi
    Hojjat Asadollahpour Nanaei
    Ali Esmailizadeh
    Scientific Reports, 13
  • [40] Identification of Genetic Effects of ACADVL and IRF6 Genes with Milk Production Traits of Holstein Cattle in China
    Peng, Peng
    Liu, Yanan
    Zheng, Weijie
    Han, Bo
    Wang, Kun
    Sun, Dongxiao
    GENES, 2022, 13 (12)