Immune microenvironment and lymph node yield in colorectal cancer

被引:6
|
作者
Lee, Soo Hyun [1 ]
Pankaj, Amaya [2 ]
Neyaz, Azfar [3 ,9 ]
Ono, Yuho [4 ,5 ]
Rickelt, Steffen [6 ]
Ferrone, Cristina [7 ]
Ting, David [2 ,5 ]
Patil, Deepa T. [5 ,8 ]
Yilmaz, Omer [3 ,5 ]
Berger, David [5 ,7 ]
Deshpande, Vikram [4 ,5 ]
Yilmaz, Osman [4 ,5 ]
机构
[1] Boston Med Ctr, Dept Pathol, Boston, MA USA
[2] Massachusetts Gen Hosp, Canc Ctr, Boston, MA USA
[3] Massachusetts Gen Hosp, Dept Pathol, Boston, MA USA
[4] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
[5] Harvard Med Sch, Boston, MA 02115 USA
[6] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA USA
[7] Massachusetts Gen Hosp, Dept Surg, Boston, MA USA
[8] Brigham & Womens Hosp, Dept Pathol, Boston, MA USA
[9] Univ Pittsburgh, Dept Pathol, Med Ctr, Pittsburgh, PA 15213 USA
关键词
COLON-CANCER; MICROSATELLITE INSTABILITY; MINIMUM NUMBER; MISMATCH-REPAIR; BETA2-MICROGLOBULIN MUTATIONS; PD-1; BLOCKADE; CLASS-I; RESECTION; SPECIMENS; SURVIVAL;
D O I
10.1038/s41416-023-02372-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundLymph node (LN) harvesting is associated with outcomes in colonic cancer. We sought to interrogate whether a distinctive immune milieu of the primary tumour is associated with LN yield.MethodsA total of 926 treatment-naive patients with colorectal adenocarcinoma with more than 12 LNs (LN-high) were compared with patients with 12 or fewer LNs (LN-low). We performed immunohistochemistry and quantification on tissue microarrays for HLA class I/II proteins, beta-2-microglobulin (B2MG), CD8, CD163, LAG3, PD-L1, FoxP3, and BRAF V600E.ResultsThe LN-high group was comprised of younger patients, longer resections, larger tumours, right-sided location, and tumours with deficient mismatch repair (dMMR). The tumour microenvironment showed higher CD8+ cells infiltration and B2MG expression on tumour cells in the LN-high group compared to the LN-low group. The estimated mean disease-specific survival was higher in the LN-high group than LN-low group. On multivariate analysis for prognosis, LN yield, CD8+ cells, extramural venous invasion, perineural invasion, and AJCC stage were independent prognostic factors.ConclusionOur findings corroborate that higher LN yield is associated with a survival benefit. LN yield is associated with an immune high microenvironment, suggesting that tumour immune milieu influences the LN yield.
引用
收藏
页码:917 / 924
页数:8
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