Therapeutic Potential of Seaweed-Derived Laminaran: Attenuation of Clinical Drug Cytotoxicity and Reactive Oxygen Species Scavenging

被引:3
|
作者
Kurokawa, Hiromi [1 ,2 ]
Marella, Thomas Kiran [1 ,2 ]
Matsui, Hirofumi [1 ,2 ]
Kuroki, Yutaka [3 ]
Watanabe, Makoto M. [1 ]
机构
[1] Univ Tsukuba, Algae Biomass Energy Syst R&D Ctr, Tennodai 1-1-1, Tsukuba 3058572, Japan
[2] Univ Tsukuba, Fac Med, Tennodai 1-1-1, Tsukuba 3058575, Japan
[3] Delightex Pte Ltd, 230 Victoria St,15-01 Bugis,Junct Towers, Singapore 188024, Singapore
关键词
laminaran; seaweed; reactive oxygen species; antioxidant; electron spin resonance; AUREOBASIDIUM-PULLULANS; LIPID-PEROXIDATION; DIETARY FIBER; SUPEROXIDE; DISEASE; GLUCAN;
D O I
10.3390/antiox12071328
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
& beta;-glucan has been shown to be effective for several diseases such as immune regulation and blood pressure suppression. Seaweed contains a & beta;-1,3/1,6-glucan called laminaran. The present commercial source of & beta;-glucan is black yeast; however, a fermentation process using organic carbon substrates makes production unsustainable, whereas macroalgae provide a sustainable alternative with the use of CO2 and seawater as growth substrates. However, bioactivity studies on laminaran are limited. We aimed to evaluate whether laminaran can scavenge reactive oxygen species (ROS) and attenuate cytotoxicity caused by clinical drugs such as indomethacin (Ind) and dabigatran (Dab). Electron spin resonance assay revealed that laminaran scavenged singlet oxygen (O-1(2)) and superoxide anions (O-2(& BULL;)-) directly but did not scavenge hydroxyl radicals ((OH)-O-& BULL;). Mitochondrial ROS detection dye showed that laminaran scavenged mitochondrial O-2(& BULL;)- produced upon administration of Ind or Dab. Moreover, significant reductions in (OH)-O-& BULL; and peroxynitrate (ONOO-) levels were observed. Since (OH)-O-& BULL; and ONOO- are generated from O-2(& BULL;)- in the cells, laminaran could indirectly suppress the generation of (OH)-O-& BULL; and ONOO- via the removal of O-2(& BULL;)-. Both Ind and Dab induce cell injury via ROS production. Laminaran attenuated the cytotoxicity derived from these drugs and may represent a functional food with anti-aging and disease prevention properties.
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页数:12
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