Family and personal history of cancer in the All of Us research program for precision medicine

被引：1

作者：

Bruce, Lauryn Keeler ^{[1
]}

Paul, Paulina A. ^{[1
]}

Kim, Katherine K. ^{[2
]}

Kim, Jihoon ^{[1
]}

Keegan, Theresa H. M. ^{[3
]}

Hiatt, Robert A. ^{[4
,5
]}

Ohno-Machado, Lucila ^{[6
]}

机构：

[1] Univ Calif UC San Diego, Dept Biomed Informat, La Jolla, CA 92093 USA

[2] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA USA

[3] Univ Calif Davis, Ctr Oncol Hematol Outcomes Res & Training, Sch Med, Div Hematol & Oncol, Davis, CA USA

[4] UC San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[5] UC San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[6] Yale Univ, Sch Med, Sect Biomed Informat & Data Sci, New Haven, CT USA

[7] NIH, All Us Res Program, Bethesda, MD USA

来源：

PLOS ONE | 2023年 / 18卷 / 07期

关键词：

OVARIAN-CANCER; PREVALENCE; BREAST;

D O I：

10.1371/journal.pone.0288496

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The All of Us (AoU) Research Program is making available one of the largest and most diverse collections of health data in the US to researchers. Using the All of Us database, we evaluated family and personal histories of five common types of cancer in 89,453 individuals, comparing these data to 24,305 participants from the 2015 National Health Interview Survey (NHIS). Comparing datasets, we found similar family cancer history (33%) rates, but higher personal cancer history in the AoU dataset (9.2% in AoU vs. 5.11% in NHIS), Methodological (e.g. survey-versus telephone-based data collection) and demographic variability may explain these between-data differences, but more research is needed.

引用

页数：12

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