Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation

被引：3
|
作者：
Zhu, Jing [1 ]
Huang, Fei [1 ,2 ]
Hu, Yonglin [1 ,3 ]
Qiao, Wei [1 ]
Guan, Yingchao [1 ]
Zhang, Zhi-Jun [1 ]
Liu, Su [1 ,5 ]
Liu, Ying [4 ]
机构：
[1] Nantong Univ, Med Sch, Affiliated Hosp, Dept Rehabil Med, Nantong 226001, Jiangsu, Peoples R China
[2] Nantong Hlth Coll Jiangsu Prov, Dept Rehabil Med, Nantong 226010, Jiangsu, Peoples R China
[3] Nantong Univ, Affiliated Nantong Rehabil Hosp, Nantong 226001, Jiangsu, Peoples R China
[4] Nantong Univ, Affiliated Hosp, Dept Pathol, Nantong 226001, Jiangsu, Peoples R China
[5] Nantong Univ, Affiliated Hosp, Dept Rehabil Med, Nantong 226001, Jiangsu, Peoples R China
来源：
JOURNAL OF INFLAMMATION RESEARCH | 2023年 / 16卷
基金：
中国国家自然科学基金;
关键词：
non -coding RNAs; neuroinflammation; neuropathic pain; spinal cord injury; ASTROCYTE PROLIFERATION; MICROGLIA ACTIVATION; NEURONS CONTRIBUTES; FUNCTIONAL RECOVERY; DOWN-REGULATION; EMERGING ROLES; UP-REGULATION; INFLAMMATION; PREVALENCE; MECHANISMS;
D O I：
10.2147/JIR.S413264
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Secondary chronic neuropathic pain (NP) in addition to sensory, motor, or autonomic dysfunction can significantly reduce quality of life after spinal cord injury (SCI). The mechanisms of SCI-related NP have been studied in clinical trials and with the use of experimental models. However, in developing new treatment strategies for SCI patients, NP poses new challenges. The inflammatory response following SCI promotes the development of NP. Previous studies suggest that reducing neuroinflammation following SCI can improve NP-related behaviors. Intensive studies of the roles of non-coding RNAs in SCI have discovered that ncRNAs bind target mRNA, act between activated glia, neuronal cells, or other immunocytes, regulate gene expression, inhibit inflammation, and influence the prognosis of NP.
引用
收藏
页码：2477 / 2489
页数：13
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