Human Derived Dermal Fibroblasts as in Vitro Research Tool to Study Circadian Rhythmicity in Psychiatric Disorders

被引：3

作者：

Palm, Denise ^{[1
]}

Uzoni, Adriana ^{[1
]}

Kronenberg, Golo ^{[1
]}

Thome, Johannes ^{[1
]}

Faltraco, Frank ^{[1
,2
]}

机构：

[1] Univ Med Ctr Rostock, Dept Psychiat & Psychotherapy, Rostock, Germany

[2] Univ Med Ctr Rostock, Dept Psychiat & Psychotherapy, Gehlsheimer Str 20, D-18147 Rostock, Germany

来源：

PHARMACOPSYCHIATRY | 2023年 / 56卷 / 03期

关键词：

human-derived fibroblasts; psychiatric disorders; sleep-wake rhythm disruptions; circadian genes; DEPENDENT PROTEIN-KINASE; CLOCK GENE PER2; ALZHEIMERS-DISEASE; BIPOLAR DISORDER; TYROSINE TRANSPORT; OXIDATIVE STRESS; INDIVIDUAL FIBROBLASTS; DOPAMINE TRANSPORTER; SIGNAL-TRANSDUCTION; RESPONSE ELEMENT;

D O I：

10.1055/a-1147-1552

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A number of psychiatric disorders are defined by persistent or recurrent sleep-wake disturbances alongside disruptions in circadian rhythm and altered clock gene expression. Circadian rhythms are present not only in the hypothalamic suprachiasmatic nucleus but also in peripheral tissues. In this respect, cultures of human derived dermal fibroblasts may serve as a promising new tool to investigate cellular and molecular mechanisms underlying the pathophysiology of mental illness. In this article, we discuss the advantages of fibroblast cultures to study psychiatric disease. More specifically, we provide an update on recent advances in modeling circadian rhythm disorders using human fibroblasts.

引用

页码：87 / 100

页数：14

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