Molecular mechanism underlying desensitization of the human proton-activated chloride (PAC) channel

被引：0
|
作者：
Osei-Owusu, James [1 ]
Ruan, Zheng [2 ]
Matasic, Daniel S. [3 ]
Lu, Wei [2 ]
Qiu, Zhaozhu [1 ]
机构：
[1] Johns Hopkins Univ, Physiol, Baltimore, MD USA
[2] Van Andel Res Inst, Grand Rapids, MI USA
[3] Johns Hopkins Univ Hosp, Med, Baltimore, MD 21287 USA
来源：
BIOPHYSICAL JOURNAL | 2023年 / 122卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2229-Plat
引用
收藏
页码：458A / 459A
页数：2
相关论文
共 50 条
  • [1] Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC
    Osei-Owusu, James
    Ruan, Zheng
    Mihaljevic, Ljubica
    Matasic, Daniel S.
    Chen, Kevin Hong
    Lue, Wei
    Qiu, Zhaozhu
    Csanady, Laszlo
    ELIFE, 2022, 11
  • [2] Structures of Human Proton-Activated Chloride Channel (PAC) Reveal Mechanism of pH Sensing and Gating
    Osei-Owusu, James
    Ruan, Zheng
    Du, Juan
    Lu, Wei
    Qiu, Zhaozhu
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 192A - 192A
  • [3] PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
    Yang, Junhua
    Chen, Jianan
    Vitery, Maria del Carmen
    Osei-Owusu, James
    Chu, Jiachen
    Yu, Haiyang
    Sun, Shuying
    Qiu, Zhaozhu
    SCIENCE, 2019, 364 (6438) : 395 - +
  • [4] Gating choreography and mechanism of the human proton-activated chloride channel ASOR
    Wang, Chongyuan
    Polovitskaya, Maya M.
    Delgado, Bryce D.
    Jentsch, Thomas J.
    Long, Stephen B.
    SCIENCE ADVANCES, 2022, 8 (05):
  • [5] Inhibition of the proton-activated chloride channel PAC by PIP2
    Mihaljevic, Ljubica
    Ruan, Zheng
    Osei-Owusu, James
    Lu, Wei
    Qiu, Zhaozhu
    ELIFE, 2023, 12
  • [6] Modulation of proton-activated chloride (PAC) channel by PIP2
    Mihaljevic, Ljubica
    Ruan, Zheng
    Osei-Owusu, James
    Lu, Wei
    Qiu, Zhaozhu
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 506A - 507A
  • [7] Characterization of a proton-activated chloride channel
    Bompadre, SG
    Hu, SH
    Hwang, TC
    BIOPHYSICAL JOURNAL, 2001, 80 (01) : 468A - 468A
  • [8] Molecular determinants of pH sensing in the proton-activated chloride channel
    Osei-Owusu, James
    Kots, Ekaterina
    Ruan, Zheng
    Mihaljevic, Ljubica
    Chen, Kevin Hong
    Tamhaney, Ami
    Ye, Xinyu
    Lu, Wei
    Weinstein, Harel
    Qiu, Zhaozhu
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (31)
  • [9] Structural insight of the proton-activated chloride (PAC) channel revealed by cryo-EM
    Ruan, Zheng
    Osei-Owusu, James
    Du, Juan
    Qiu, Zhaozhu
    Lu, Wei
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 506A - 506A
  • [10] Structures and pH-sensing mechanism of the proton-activated chloride channel
    Zheng Ruan
    James Osei-Owusu
    Juan Du
    Zhaozhu Qiu
    Wei Lü
    Nature, 2020, 588 : 350 - 354
12345