Role of platelet function and genetic testing in patients undergoing percutaneous coronary intervention

被引:33
作者
Galli, Mattia [1 ,2 ]
Franchi, Francesco [1 ]
Rollini, Fabiana [1 ]
Angiolillo, Dominick J. [1 ,3 ]
机构
[1] Univ Florida, Div Cardiol, Coll Med, Jacksonville, FL USA
[2] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Dept Cardiovasc & Thorac Sci, Rome, Italy
[3] Univ Florida, Coll Med, 655 West 8th St, Jacksonville, FL 32209 USA
关键词
Genetic testing; Platelet function testing; Antiplatelet therapy; Guided selection; Percutaneous coronary intervention; P2Y; 12; inhibitors; GUIDED ANTIPLATELET THERAPY; P2Y(12) INHIBITOR THERAPY; HIGH-DOSE CLOPIDOGREL; CYP2C19; GENOTYPE; OPEN-LABEL; TICAGRELOR; OUTCOMES; PCI; REACTIVITY; PRASUGREL;
D O I
10.1016/j.tcm.2021.12.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Dual antiplatelet therapy (DAPT) represents the standard of care for patients undergoing percutaneous coronary intervention (PCI). Increasing evidence indicates that a "one-size-fits-all" approach with the use of a standard DAPT regimen for all patients undergoing PCI could lead to either suboptimal efficacy or prohibitively high bleeding in specific cohorts of patients. Moreover, the broad interindividual variabil-ity in response to P2Y12 inhibitors can impact outcomes and resource utilization. Among the strategies proposed to provide a more balanced trade-off between bleeding and ischemic events at a single pa-tient level, a guided selection of P2Y12 inhibitors, by using platelet function or genetic testing, has shown promising results. In this review, we provide a focused summary of the rationale and evidence on the use of platelet function and genetic testing-guided antiplatelet therapy, and we explore the implications for their use in the modern setting of patients undergoing PCI.(c) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码:133 / 138
页数:6
相关论文
共 37 条
[1]  
Angiolillo DJ, 2021, EUROINTERVENTION
[2]   Variability in individual responsiveness to clopidogrel - Clinical implications, management, and future perspectives [J].
Angiolillo, Dominick J. ;
Fernandez-Ortiz, Antonio ;
Bernardo, Esther ;
Alfonso, Fernando ;
Macaya, Carlos ;
Bass, Theodore A. ;
Costa, Marco A. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (14) :1505-1516
[3]   Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel The ABCD-GENE Score [J].
Angiolillo, Dominick J. ;
Capodanno, Davide ;
Danchin, Nicolas ;
Simon, Tabassome ;
Bergmeijer, Thomas O. ;
ten Berg, Jurrien M. ;
Sibbing, Dirk ;
Price, Matthew J. .
JACC-CARDIOVASCULAR INTERVENTIONS, 2020, 13 (05) :606-617
[4]   Dual antiplatelet therapy guided by platelet function testing [J].
Angiolillo, Dominick J. .
LANCET, 2017, 390 (10104) :1718-1720
[5]   Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary intervention [J].
Aradi, Daniel ;
Kirtane, Ajay ;
Bonello, Laurent ;
Gurbel, Paul A. ;
Tantry, Udaya S. ;
Huber, Kurt ;
Freynhofer, Matthias K. ;
ten Berg, Jurrien ;
Janssen, Paul ;
Angiolillo, Dominick J. ;
Siller-Matula, Jolanta M. ;
Marcucci, Rossella ;
Patti, Giuseppe ;
Mangiacapra, Fabio ;
Valgimigli, Marco ;
Morel, Olivier ;
Palmerini, Tullio ;
Price, Matthew J. ;
Cuisset, Thomas ;
Kastrati, Adnan ;
Stone, GreggW. ;
Sibbing, Dirk .
EUROPEAN HEART JOURNAL, 2015, 36 (27) :1762-1771
[6]   Bleeding after antiplatelet therapy for the treatment of acute coronary syndromes: a review of the evidence and evolving paradigms [J].
Buccheri, Sergio ;
Capodanno, Davide ;
James, Stefan ;
Angiolillo, Dominick J. .
EXPERT OPINION ON DRUG SAFETY, 2019, 18 (12) :1171-1189
[7]   Bleeding avoidance strategies in percutaneous coronary intervention [J].
Capodanno, Davide ;
Bhatt, Deepak L. ;
Gibson, C. Michael ;
James, Stefan ;
Kimura, Takeshi ;
Mehran, Roxana ;
Rao, Sunil, V ;
Steg, Philippe Gabriel ;
Urban, Philip ;
Valgimigli, Marco ;
Windecker, Stephan ;
Angiolillo, Dominick J. .
NATURE REVIEWS CARDIOLOGY, 2022, 19 (02) :117-132
[8]   ACC/AHA Versus ESC Guidelines on Dual Antiplatelet Therapy JACC Guideline Comparison [J].
Capodanno, Davide ;
Alfonso, Fernando ;
Levine, Glenn N. ;
Valgimigli, Marco ;
Angiolillo, Dominick J. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 72 (23) :2915-2931
[9]   Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention [J].
Cavallari, Larisa H. ;
Lee, Craig R. ;
Beitelshees, Amber L. ;
Cooper-DeHoff, Rhonda M. ;
Duarte, Julio D. ;
Voora, Deepak ;
Kimmel, Stephen E. ;
McDonough, Caitrin W. ;
Gong, Yan ;
Dave, Chintan V. ;
Pratt, Victoria M. ;
Alestock, Tameka D. ;
Anderson, R. David ;
Alsip, Jorge ;
Ardati, Amer K. ;
Brott, Brigitta C. ;
Brown, Lawrence ;
Chumnumwat, Supatat ;
Clare-Salzler, Michael J. ;
Coons, James C. ;
Denny, Joshua C. ;
Dillon, Chrisly ;
Elsey, Amanda R. ;
Hamadeh, Issam S. ;
Harada, Shuko ;
Hillegass, William B. ;
Hines, Lindsay ;
Horenstein, Richard B. ;
Howell, Lucius A. ;
Jeng, Linda J. B. ;
Kelemen, Mark D. ;
Lee, Yee Ming ;
Magvanjav, Oyunbileg ;
Montasser, May ;
Nelson, David R. ;
Nutescu, Edith A. ;
Nwaba, Devon C. ;
Pakyz, Ruth E. ;
Palmer, Kathleen ;
Peterson, Josh F. ;
Pollin, Toni I. ;
Quinn, Alison H. ;
Robinson, Shawn W. ;
Schub, Jamie ;
Skaar, Todd C. ;
Smith, D. Max ;
Sriramoju, Vindhya B. ;
Starostik, Petr ;
Stys, Tomasz P. ;
Stevenson, James M. .
JACC-CARDIOVASCULAR INTERVENTIONS, 2018, 11 (02) :181-191
[10]   A Genotype-Guided Strategy for Oral P2Y12 Inhibitors in Primary PCI [J].
Claassens, Daniel M. F. ;
Vos, Gerrit J. A. ;
Bergmeijer, Thomas O. ;
Hermanides, Renicus S. ;
van 't Hof, Arnoud W. J. ;
van der Harst, Pim ;
Barbato, Emanuele ;
Morisco, Carmine ;
Gin, Richard M. Tjon Joe ;
Asselbergs, Folkert W. ;
Mosterd, Arend ;
Herrman, Jean-Paul R. ;
Dewilde, Willem J. M. ;
Janssen, Paul W. A. ;
Kelder, Johannes C. ;
Postma, Maarten J. ;
de Boer, Anthonius ;
Boersma, Cornelis ;
Deneer, Vera H. M. ;
ten Berg, Jurrien M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (17) :1621-1631