Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

被引：25

作者：

Rigat, Ludovica ^{[1
,2
]}

Ouk, Koliane ^{[1
,2
]}

Kramer, Achim ^{[3
]}

Priller, Josef ^{[1
,2
,4
,5
,6
,7
,8
]}

机构：

[1] Charite Univ Med Berlin, Neuropsychiat, Charitepl 1, D-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Lab Mol Psychiat, Charitepl 1, D-10117 Berlin, Germany

[3] Charite Univ Med Berlin, Div Chronobiol, Charitepl 1, D-10117 Berlin, Germany

[4] German Ctr Neurodegenerat Dis DZNE, D-10117 Berlin, Germany

[5] Tech Univ Munich, Sch Med & Hlth, Dept Psychiat & Psychotherapy, Ismaninger Str 22, D-81675 Munich, Germany

[6] UK Dementia Res Inst, Ctr Clin Brain Sci, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland

[7] Charite Univ Med Berlin, Neuropsychiat, Charitepl 1, D-10117 Berlin, Germany

[8] Charite Univ Med Berlin, Lab Mol Psychiat, Charitepl 1, D-10117 Berlin, Germany

来源：

ACTA PHYSIOLOGICA | 2023年 / 238卷 / 02期

关键词：

Alzheimer's disease; circadian system; clock; neurodegeneration; sleep; LIGHT THERAPY; COGNITIVE IMPAIRMENT; CLOCK PROTEINS; BRIGHT-LIGHT; SHIFT WORK; REV-ERB; MELATONIN; DEMENTIA; TIME; CRYPTOCHROME;

D O I：

10.1111/apha.13970

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Dysfunction of circadian and sleep rhythms is an early feature of many neurodegenerative diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive and psychiatric disturbances. Although it is largely unclear whether dysfunctions in sleep and circadian rhythms contribute to the etiology of AD or are a consequence of the disease, there is evidence that these conditions are involved in a complex self-reinforcing bidirectional relationship. According to the recent studies, dysregulation of the circadian clock already occurs during the asymptomatic stage of the disease and could promote neurodegeneration. Thus, restoration of sleep and circadian rhythms in preclinical AD may represent an opportunity for early intervention to slow the disease course.

引用

页数：13

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