GATA3 Expression in Human Tumors: A Tissue Microarray Study on 16,557 Tumors

被引：22

作者：

Reiswich, Viktor ^{[1
]}

Schmidt, Carol E. ^{[1
]}

Lennartz, Maximilian ^{[1
]}

Hoeflmayer, Doris ^{[1
]}

Hube-Magg, Claudia ^{[1
]}

Weidemann, Soren ^{[1
]}

Fraune, Christoph ^{[1
]}

Buescheck, Franziska ^{[1
]}

Moeller, Katharina ^{[1
]}

Bernreuther, Christian ^{[1
]}

Simon, Ronald ^{[1
]}

Clauditz, Till S. ^{[1
]}

Blessin, Niclas C. ^{[1
]}

Bady, Elena ^{[1
]}

Sauter, Guido ^{[1
]}

Uhlig, Ria ^{[1
]}

Steurer, Stefan ^{[1
]}

Minner, Sarah ^{[1
]}

Burandt, Eike ^{[1
]}

Dum, David ^{[1
]}

Marx, Andreas H. ^{[1
,2
]}

Krech, Till ^{[1
,3
]}

Lebok, Patrick ^{[1
,3
]}

Hinsch, Andrea ^{[1
]}

Jacobsen, Frank ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Inst Pathol, Hamburg, Germany

[2] Acad Hosp Fuerth, Dept Pathol, Furth, Germany

[3] Clin Ctr Osnabrueck, Inst Pathol, Osnabruck, Germany

来源：

PATHOBIOLOGY | 2023年 / 90卷 / 04期

关键词：

GATA3; Tissue microarray; Immunohistochemistry; Human carcinomas; BINDING-PROTEIN; 3; BREAST-CARCINOMA; UROTHELIAL CARCINOMA; IMMUNOHISTOCHEMICAL EXPRESSION; DIFFERENTIAL-DIAGNOSIS; TROPHOBLASTIC TISSUES; TRANSCRIPTION FACTOR; ESTROGEN-RECEPTOR; USEFUL MARKER; CANCER;

D O I：

10.1159/000527382

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Introduction: GATA3 is a transcription factor involved in epithelial cell differentiation. GATA3 immunostaining is used as a diagnostic marker for breast and urothelial cancer but can also occur in other neoplasms. Methods: To evaluate GATA3 in normal and tumor tissues, a tissue microarray containing 16,557 samples from 131 different tumor types and subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. Results: GATA3 positivity was found in 69 different tumor types including 23 types (18%) with at least one strongly positive tumor. Highest positivity rates occurred in noninvasive papillary urothelial carcinoma (92-99%), lobular carcinoma (98%), carcinoma of no special type of the breast (92%), basal cell carcinoma of the skin (97%), invasive urothelial carcinoma (73%), T-cell lymphoma (23%), adenocarcinoma of the salivary gland (16%), squamous cell carcinoma of the skin (16%), and colorectal neuroendocrine carcinoma (12%). In breast cancer, low GATA3 staining was linked to high pT stage (p = 0.03), high BRE grade (p < 0.0001), HER2 overexpression (p = 0.0085), estrogen and progesterone receptor negativity (p < 0.0001 each), and reduced survival (p = 0.03). Conclusion: Our data demonstrate that GATA3 positivity can occur in various tumor entities. Low levels of GATA3 reflect cancer progression and poor patient prognosis in breast cancer.

引用

页码：219 / 232

页数：14

共 81 条

[1] Loss of expression of the SWI/SNF complex is a frequent event in undifferentiated/dedifferentiated urothelial carcinoma of the urinary tract [J].

Agaimy, Abbas ;

Bertz, Simone ;

Cheng, Liang ;

Hes, Ondrej ;

Junker, Kerstin ;

Keck, Bastian ;

Lopez-Beltran, Antonio ;

Stoeckle, Michael ;

Wullich, Bernd ;

Hartmann, Arndt .

VIRCHOWS ARCHIV, 2016, 469 (03) :321-330

[2] Diagnostic utility of GATA3 immunohistochemical expression in urothelial carcinoma [J].

Agarwal, Harshita ;

Babu, Suresh ;

Rana, Chanchal ;

Kumar, Madhu ;

Singhai, Atin ;

Shankhwar, Shiv Narayan ;

Singh, Vishwajeet ;

Sinha, Rahul Janak .

INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2019, 62 (02) :244-250

[3] Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours [J].

Albergaria, Andre ;

Paredes, Joana ;

Sousa, Barbara ;

Milanezi, Fernanda ;

Carneiro, Vitor ;

Bastos, Joana ;

Costa, Sandra ;

Vieira, Daniella ;

Lopes, Nair ;

Lam, Eric W. ;

Lunet, Nuno ;

Schmitt, Fernando .

BREAST CANCER RESEARCH, 2009, 11 (03)

[4]

Banet N, 2015, AM J SURG PATHOL, V39, P101, DOI 10.1097/PAS.0000000000000315

[5] Impact of immunohistochemistry-based subtyping of GATA3, CK20, CK5/6, and CK14 expression on survival after radical cystectomy for muscle-invasive bladder cancer [J].

Bejrananda, Tanan ;

Kanjanapradit, Kanet ;

Saetang, Jirakrit ;

Sangkhathat, Surasak .

SCIENTIFIC REPORTS, 2021, 11 (01)

[6] GATA3 shows differential immunohistochemical expression across thyroid and parathyroid lesions [J].

Betts, Guy ;

Beckett, Elizabeth ;

Nonaka, Daisuke .

HISTOPATHOLOGY, 2014, 65 (02) :288-290

[7] Proximal CD13 Versus Distal GATA-3 Expression in Renal Neoplasia According to WHO 2016 Classification [J].

Brunelli, Matteo ;

Erdini, Francesco ;

Cima, Luca ;

Eccher, Albino ;

Fioravanzo, Adele ;

Gobbo, Stefano ;

Segala, Diego ;

Ghimenton, Claudio ;

Mazzoleni, Guido ;

Munari, Enrico ;

Carella, Rodolfo ;

Martignoni, Guido .

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2018, 26 (05) :316-323

[8] Renal cell carcinoma [J].

Cairns, Paul .

CANCER BIOMARKERS, 2011, 9 (1-6) :461-473

[9] GATA3 expression and its relationship with clinicopathological parameters in invasive breast carcinomas [J].

Cakir, A. ;

Gonul, I. Isik ;

Ekinci, O. ;

Cetin, B. ;

Benekli, M. ;

Uluoglu, O. .

PATHOLOGY RESEARCH AND PRACTICE, 2017, 213 (03) :227-234

[10] The Diagnostic Value of Cytokeratin 5/6, 14, 17, and 18 Expression in Human Non-Small Cell Lung Cancer [J].

Chen, Yuan ;

Cui, Tiantian ;

Yang, Linlin ;

Mireskandari, Masoud ;

Knoesel, Thomas ;

Zhang, Qing ;

Pacyna-Gengelbach, Manuela ;

Petersen, Iver .

ONCOLOGY, 2011, 80 (5-6) :333-340

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