Interleukin 15 in murine models of colitis

被引:2
|
作者
Kautzman, Alicia Molina [1 ]
Mobulakani, Jeanne Masunga Faida [1 ]
Cofino, Gisela Marrero [2 ]
Quenum, Akouavi Julite Irmine [1 ]
Cayarga, Anny Armas [1 ]
Asselin, Claude [1 ,3 ]
Fortier, Louis-Charles [2 ,3 ]
Ilangumaran, Subburaj [1 ,3 ]
Menendez, Alfredo [2 ,3 ]
Ramanathan, Sheela [1 ,3 ]
机构
[1] Univ Sherbrooke, Dept Immunol & Cell Biol, Sherbrooke, PQ, Canada
[2] Univ Sherbrooke, Dept Microbiol & Infect Dis, Sherbrooke, PQ, Canada
[3] CRCHUS, Sherbrooke, PQ, Canada
来源
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2023年 / 306卷 / 05期
基金
加拿大自然科学与工程研究理事会;
关键词
colitis; IL-15; Salmonella; DEXTRAN SULFATE SODIUM; CITROBACTER-RODENTIUM INFECTION; PLASMACYTOID DENDRITIC CELLS; T-LYMPHOCYTE DEVELOPMENT; RECEPTOR-BETA-CHAIN; TCR-ALPHA-BETA; SEROVAR TYPHIMURIUM; IMMUNE-RESPONSES; INTESTINAL INFLAMMATION; TRANS-PRESENTATION;
D O I
10.1002/ar.25044
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Inflammatory bowel diseases (IBDs) are characterized by abnormal, non-antigen specific chronic inflammation of unknown etiology. Genome-wide association studies show that many IBD genetic susceptibility loci map to immune function genes and compelling evidence indicate that environmental factors play a critical role in IBD pathogenesis. Clinical and experimental evidence implicate the pro-inflammatory cytokine IL-15 in the pathogenesis of IBD. IL-15 and IL-15 alpha expression is increased in the inflamed mucosa of IBD patients. IL-15 contributes to the maintenance of different cell subsets in the intestinal mucosa. However, very few studies have addressed the role of IL-15 in pre-clinical models of colitis. In this study, we use three well-characterized models of experimental colitis to determine the contribution of IL-15 to pathological intestinal inflammation.
引用
收藏
页码:1111 / 1130
页数:20
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