Relationship of mTORC1 and ferroptosis in tumors

被引:3
|
作者
Liao, Huilin [1 ,3 ]
Wang, Yueqing [1 ,3 ]
Zou, Lili [1 ,3 ]
Fan, Yanmei [1 ]
Wang, Xinyue [1 ]
Tu, Xiancong [1 ]
Zhu, Qiaobai [1 ,3 ]
Wang, Jun [4 ,5 ]
Liu, Xiaowen [1 ,3 ]
Dong, Chuanjiang [2 ]
机构
[1] China Three Gorges Univ, Coll Basic Med Sci, Hubei Key Lab Tumor Microenvironm & Immunotherapy, Yichang 443002, Hubei, Peoples R China
[2] Guangdong Med Univ, Dept Urol, Dongguan Affiliated Hosp 1, Dongguan 523000, Guangdong, Peoples R China
[3] China Three Gorges Univ, Inst Infect & Inflammat, Coll Basic Med Sci, Yichang 443002, Hubei, Peoples R China
[4] China Three Gorges Univ, Peoples Hosp, Yichang 443002, Hubei, Peoples R China
[5] First Peoples Hosp Yichang, Yichang 443002, Hubei, Peoples R China
关键词
Ferroptosis; mTOR; AMPK; Autophagy; GPX4; Tumors; TRANSLATION INITIATION; LIPID-PEROXIDATION; SIGNALING PATHWAY; BLADDER-CANCER; CELL-DEATH; AUTOPHAGY; IRON; PHOSPHORYLATION; ACTIVATION; GROWTH;
D O I
10.1007/s12672-024-00954-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracellular form of lipid peroxidation. In recent years, ferroptosis has gained more and more interest of people in the treatment mechanism of targeted tumors. mTOR, always overexpressed in the tumor, and controlling cell growth and metabolic activities, has an important role in both autophagy and ferroptosis. Interestingly, the selective types of autophay plays an important role in promoting ferroptosis, which is related to mTOR and some metabolic pathways (especially in iron and amino acids). In this paper, we list the main mechanisms linking ferroptosis with mTOR signaling pathway and further summarize the current compounds targeting ferroptosis in these ways. There are growing experimental evidences that targeting mTOR and ferroptosis may have effective impact in many tumors, and understanding the mechanisms linking mTOR to ferroptosis could provide a potential therapeutic approach for tumor treatment.
引用
收藏
页数:11
相关论文
共 50 条
  • [31] mTORC1 signaling in hepatic lipid metabolism
    Han, Jinbo
    Wang, Yiguo
    PROTEIN & CELL, 2018, 9 (02) : 145 - 151
  • [32] How mTORC1 makes sense of nutrients
    Luciani, Alessandro
    Stagi, Massimiliano
    KIDNEY INTERNATIONAL, 2021, 99 (02) : 295 - 298
  • [33] The anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway
    Tamaddoni, Ahmad
    Mohammadi, Elahe
    Sedaghat, Fatemeh
    Qujeq, Durdi
    As'Habi, Atefeh
    PHARMACOLOGICAL RESEARCH, 2020, 156
  • [34] Regulation of mTORC1 by the Rab and Arf GTPases
    Li, Li
    Kim, Eunjung
    Yuan, Haixin
    Inoki, Ken
    Goraksha-Hicks, Pankuri
    Schiesher, Rachel L.
    Neufeld, Thomas P.
    Guan, Kun-Liang
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (26) : 19705 - 19709
  • [35] The expression and significance of mTORC1 in diabetic retinopathy
    Liu, Yanli
    Zheng, Yarong
    Zhou, Yekai
    Liu, Yi
    Xie, Mengxuan
    Meng, Wenjing
    An, Meixia
    BMC OPHTHALMOLOGY, 2020, 20 (01)
  • [36] The combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro
    Becker, Marie N.
    Wu, Kevin J.
    Marlow, Laura A.
    Kreinest, Pamela A.
    vonRoemeling, Christina A.
    Copland, John A.
    Williams, Christopher R.
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2014, 32 (03) : 317 - 326
  • [37] Fertilization-Induced Autophagy in Mouse Embryos Is Independent of mTORC1
    Yamamoto, Atsushi
    Mizushima, Noboru
    Tsukamoto, Satoshi
    BIOLOGY OF REPRODUCTION, 2014, 91 (01)
  • [38] Phosphorylation-independent mTORC1 inhibition by the autophagy inducer Rottlerin
    Torricelli, C.
    Daveri, E.
    Salvadori, S.
    Valacchi, G.
    Ietta, F.
    Muscettola, M.
    Carlucci, F.
    Maioli, E.
    CANCER LETTERS, 2015, 360 (01) : 17 - 27
  • [39] The Emerging Roles of mTORC1 in Macromanaging Autophagy
    Dossou, Akpedje S.
    Basu, Alakananda
    CANCERS, 2019, 11 (10)
  • [40] Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling
    Glazer, Hilary P.
    Osipov, Robert M.
    Clements, Richard T.
    Sellke, Frank W.
    Bianchi, Cesario
    CELL CYCLE, 2009, 8 (11) : 1738 - 1746