Recent Progress in Photoreceptor Cell-Based Therapy for Degenerative Retinal Disease

被引：4

作者：

Klymenko, Valeriia ^{[1
]}

Gonzalez Martinez, Orlando G. ^{[1
]}

Zarbin, Marco A. ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Rutgers New Jersey Med Sch, Dept Ophthalmol & Visual Sci, Newark, NJ USA

[2] Rutgers New Jersey Med Sch, 90 Bergen St,Suite 6100, Newark, NJ 07103 USA

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2024年 / 13卷 / 04期

关键词：

geographic atrophy; macular degeneration; induced pluripotent stem cells; embryonic stem cells; cell transplantation; retina; retinal pigment epithelium; retinitis pigmentosa; PIGMENT EPITHELIAL-CELLS; OCULAR IMMUNE PRIVILEGE; VISUAL FUNCTION; STEM-CELLS; RETINITIS-PIGMENTOSA; GENE-THERAPY; MULLER GLIA; EXTRACELLULAR VESICLES; MACULAR DEGENERATION; CONE PHOTORECEPTORS;

D O I：

10.1093/stcltm/szae005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of photoreceptors as treatment for these conditions are underway. In this review, we summarize recent progress in the field of photoreceptor transplantation, including some pertinent results regarding photoreceptor manufacture, photoreceptor transplantation, mechanisms of donor-host cell integration such as material transfer and photoreceptor transplant immunology. We conclude by proposing several approaches that may provide a rational basis for selecting a vision restoration strategy (eg, donor-host synapse formation vs donor-host nanotube formation) and improved transplant efficiency. Graphical Abstract

引用

页码：332 / 345

页数：14

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