Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y85

被引：2

作者：

Qin, Feng ^{[1
,2
]}

Song, Zi-Shuo ^{[1
]}

Luo, Li ^{[1
]}

Bo, Xiang-Long ^{[1
]}

Wu, Fu-Rong ^{[1
]}

Tan, Mei-Jing ^{[1
]}

Wang, Fan-Fan ^{[2
]}

Huang, Xi-Shan ^{[1
]}

Wang, Heng-Shan ^{[1
]}

机构：

[1] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Key Lab Chem & Mol Engn Med Resources, Minist Educ China,Collaborat Innovat Ctr Guangxi E, Guilin 541004, Peoples R China

[2] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China

来源：

MARINE DRUGS | 2024年 / 22卷 / 02期

基金：

中国国家自然科学基金;

关键词：

mangrove endophytic fungus; Aspergillus sp; meroterpenoids; anti-cancer activity;

D O I：

10.3390/md22020058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J-N (1-5), along with three known analogues (6-8), were obtained from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra. Cytotoxicity assay results indicated that compound 8 had strong cytotoxicity against HeLa cancer cells, and its IC50 value was 11.8 mu M. In addition, flow cytometry analysis revealed that the cytotoxicity of 8 was due to the induction of G1 cell cycle arrest and apoptosis in HeLa cells.

引用

页数：10