Whole-Brain Evaluation of Cortical Microconnectomes

被引:0
|
作者
Matsuda, Kouki [1 ]
Shirakami, Arata [1 ]
Nakajima, Ryota [1 ]
Akutsu, Tatsuya [2 ]
Shimono, Masanori [1 ,3 ]
机构
[1] Kyoto Univ, Grad Sch Med, 53 Kawaramachi,Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Univ, Inst Chem Res, Bioinformat Ctr, Uji, Kyoto 6110011, Japan
[3] Osaka Univ, Grad Sch Informat Sci & Technol, 1-5 Yamadaoka, Suita, Osaka 5650871, Japan
关键词
cortex; functional networks; network; nonuniformity; FUNCTIONAL CONNECTIVITY; NETWORK STRUCTURE; CORTEX; ORGANIZATION; INHIBITION; MODEL; HUBS; TRANSMISSION; EXCITATION; NEURONS;
D O I
10.1523/ENEURO.0094-23.2023
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The brain is an organ that functions as a network of many elements connected in a nonuniform manner. In the brain, the neocortex is evolutionarily newest and is thought to be primarily responsible for the high intelligence of mammals. In the mature mammalian brain, all cortical regions are expected to have some degree of homology, but have some variations of local circuits to achieve specific functions performed by individual regions. However, few cellular-level studies have examined how the networks within different cortical regions differ. This study aimed to find rules for systematic changes of connectivity (microconnectomes) across 16 different cortical region groups. We also observed unknown trends in basic parameters in vitro such as firing rate and layer thickness across brain regions. Results revealed that the frontal group shows unique characteristics such as dense active neurons, thick cortex, and strong connections with deeper layers. This suggests the frontal side of the cortex is inherently capable of driving, even in isolation and that frontal nodes provide the driving force generating a global pattern of spontaneous synchronous activity, such as the default mode network. This finding provides a new hypothesis explaining why disruption in the frontal region causes a large impact on mental health.
引用
收藏
页数:17
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