Interventions for Dry Eye: An Overview of Systematic Reviews

被引:8
作者
McCann, Paul [1 ]
Kruoch, Zanna [2 ]
Lopez, Sarah [4 ]
Malli, Shreya [5 ]
Qureshi, Riaz [1 ,3 ]
Li, Tianjing [1 ,3 ,6 ]
机构
[1] Univ Colorado, Dept Ophthalmol, Anschutz Med Campus, Aurora, CO 80045 USA
[2] Rocky Mt Univ Hlth Profess, Coll Optometry, Provo, UT USA
[3] Colorado Sch Publ Hlth, Dept Epidemiol, Denver, CO USA
[4] Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA USA
[5] Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA USA
[6] Univ Colorado, Sch Med, Dept Ophthalmol, Anschutz Med Campus,1675 Aurora Ct,F731, Aurora, CO 80045 USA
基金
美国国家卫生研究院;
关键词
DISEASE; METAANALYSIS; MANAGEMENT; QUALITY;
D O I
10.1001/jamaophthalmol.2023.5751
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Importance Dry eye is a common ocular disease that can have substantial morbidity. Systematic reviews provide evidence for dry eye interventions and can be useful for patients, clinicians, and clinical guideline developers. Overviews of reviews use explicit and systematic methods to synthesize findings from multiple systematic reviews, but currently, there are no overviews of systematic reviews investigating interventions for dry eye.Objective To summarize the results of reliable systematic reviews of dry eye interventions and to highlight the evidence gaps identified.Evidence Review We searched the Cochrane Eyes and Vision US satellite database and included reliable systematic reviews evaluating dry eye interventions published from 2016 to 2022. We reported the proportion of systematic reviews that were reliable with reasons for unreliability. Critical and important outcomes from reliable systematic reviews were extracted and verified. Critical outcomes included dry eye-related patient-reported outcome measures. Results were synthesized from reliable systematic reviews to provide summaries of evidence for each intervention. Evidence for each intervention was defined as conclusive or inconclusive depending on whether high-certainty evidence across systematic reviews was available according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) criteria and whether findings reached statistical or clinical significance. Recommendations were made for further research.Findings Within the Cochrane Eyes and Vision US satellite database, 138 potentially relevant systematic reviews were identified, 71 were considered eligible, and 26 (37%) were assessed as reliable. Among reliable systematic reviews, no conclusive evidence was identified for any dry eye intervention. Inconclusive evidence suggested that environmental modifications, dietary modifications, artificial tears and lubricants, punctal occlusion, intense pulsed light therapy, vectored thermal pulsation therapy (Lipiflow), topical corticosteroids, topical cyclosporine A, topical secretagogues, and autologous serum may be effective. Only unreliable systematic reviews evaluated lifitegrast, oral antibiotics, and moisture chamber devices.Conclusions and Relevance This overview of systematic reviews found some evidence that dry eye interventions may be effective, but no conclusive evidence was available. The conduct and reporting of most systematic reviews for dry eye interventions warrant improvement, and reliable systematic reviews are needed to evaluate lifitegrast, oral antibiotics, and moisture chamber devices.
引用
收藏
页码:58 / 74
页数:17
相关论文
共 73 条
[1]   Dry Eye Syndrome Preferred Practice Pattern® [J].
Akpek, Esen K. ;
Amescua, Guillermo ;
Farid, Marjan ;
Garcia-Ferrer, Francisco J. ;
Lin, Amy ;
Rhee, Michelle K. ;
Varu, Divya M. ;
Musch, David C. ;
Dunn, Steven P. ;
Mah, Francis S. .
OPHTHALMOLOGY, 2019, 126 (01) :P286-P334
[2]   Non-pharmaceutical treatment options for meibomian gland dysfunction [J].
Arita, Reiko ;
Fukuoka, Shima .
CLINICAL AND EXPERIMENTAL OPTOMETRY, 2020, 103 (06) :742-755
[3]   The Medical Dictionary for Regulatory Activities (MedDRA) [J].
Brown, EG ;
Wood, L ;
Wood, S .
DRUG SAFETY, 1999, 20 (02) :109-117
[4]   Humidification of indoor air for preventing or reducing dryness symptoms or upper respiratory infections in educational settings and at the workplace [J].
Byber, Katarzyna ;
Radtke, Thomas ;
Norbaeck, Dan ;
Hitzke, Christine ;
Imo, David ;
Schwenkglenks, Matthias ;
Puhan, Milo A. ;
Dressel, Holger ;
Mutsch, Margot .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2021, (12)
[5]   Effects of Polyunsaturated Fatty Acids on Nonspecific Typical Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials [J].
Chi, Sheng-Chu ;
Tuan, Hsin-I ;
Kang, Yi-No .
NUTRIENTS, 2019, 11 (05)
[6]   Meta-Analysis of Treatment for Primary Sjogren's Syndrome [J].
Chu, Lucy L. ;
Cui, Kangping ;
Pope, Janet E. .
ARTHRITIS CARE & RESEARCH, 2020, 72 (07) :1011-1021
[7]   Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction [J].
Cote, Sharlotta ;
Zhang, Alexis Ceecee ;
Ahmadzai, Victoria ;
Maleken, Amina ;
Li, Christine ;
Oppedisano, Jeremy ;
Nair, Kaavya ;
Busija, Ljoudmila ;
Downie, Laura E. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2020, (03)
[8]   TFOS DEWS II Definition and Classification Report [J].
Craig, Jennifer P. ;
Nichols, Kelly K. ;
Akpek, Esen K. ;
Caffery, Barbara ;
Dua, Harminder S. ;
Joo, Choun-Ki ;
Liu, Zuguo ;
Nelson, J. Daniel ;
Nichols, Jason J. ;
Tsubota, Kazuo ;
Stapleton, Fiona .
OCULAR SURFACE, 2017, 15 (03) :276-283
[9]   Topical cyclosporine A therapy for dry eye syndrome [J].
de Paiva, Cintia S. ;
Pflugfelder, Stephen C. ;
Ng, Sueko M. ;
Akpek, Esen K. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2019, (09)
[10]   Rituximab Effectiveness and Safety for Treating Primary Sjogren's Syndrome (pSS): Systematic Review and Meta-Analysis [J].
do Valle Souza, Francine Bertolais ;
Martiniano Porfirio, Gustavo Jose ;
Gomes Andriolo, Brenda Nazare ;
de Albuquerque, Julia Vajda ;
Moca Trevisani, Virginia Fernandes .
PLOS ONE, 2016, 11 (03)