PD98059 protects SH-SY5Y cells against oxidative stress in oxygen-glucose deprivation/reperfusion

被引：2
作者：
Zhuge, Xiang-Zhen [1 ]
Hu, Wan-Xiang [1 ]
Liu, Yu-Mei [2 ]
Jiang, Chang-Yue [3 ,4 ]
Zhang, Xiao-Hua [1 ]
Chen, Meng-Hua [5 ]
Xie, Lu [1 ]
机构：
[1] Guangxi Med Univ, Dept Physiol, Preclin Sci, 22 Shuangyong Rd, Nanning 350001, Guangxi, Peoples R China
[2] Shenzhen Bay Lab Neuropathy Inst China, Shenzhen 518107, Guangdong, Peoples R China
[3] HIV AIDS Clin Treatment Ctr Guangxi Nanning, Dept Pharm, Nanning 530000, Peoples R China
[4] Fourth Peoples Hosp Nanning, Nanning 530000, Peoples R China
[5] Guangxi Med Univ, Hosp 2, Inst Cardiovasc Dis, Nanning 530000, Guangxi, Peoples R China
来源：
TRANSLATIONAL NEUROSCIENCE | 2023年 / 14卷 / 01期
基金：
中国国家自然科学基金;
关键词：
extracellular signal-regulated kinase; oxidative stress; mitochondria; apoptosis; ISCHEMIA-REPERFUSION INJURY; MITOCHONDRIAL FUSION; CEREBRAL-ISCHEMIA; SIGNALING PATHWAY; FISSION; INHIBITION; NEURONS; ERK1/2; RATS;
D O I：
10.1515/tnsci-2022-0300
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Mitochondria play a key role in the cerebral ischemia-reperfusion injury. Although the extracellular signal-regulated kinase 1/2 inhibitor PD98059 (PD) is a selective and reversible flavonoid that can protect the mitochondria in a rat model of cardiac arrest/cardiopulmonary resuscitation, its role requires further confirmation. In this study, we investigated whether PD could maintain mitochondrial homeostasis and decrease reactive oxygen species (ROS) production in neuroblastoma (SH-SY5Y) cells exposed to oxygen-glucose deprivation/reperfusion (OGD/R). PD improved the mitochondrial morphology and function, reversed the increase in ROS production and cell apoptosis, and reduced total-superoxide dismutase and Mn-superoxide dismutase activities induced by OGD/R. PD decreases ROS production and improves mitochondrial morphology and function, protecting SH-SY5Y cells against OGD/R-induced injury.
引用
收藏
页数：12
相关论文
共 50 条
  • [41] Protective Effects of Flavonoids Against Oxidative Stress Induced by Simulated Microgravity in SH-SY5Y Cells
    Qu, Lina
    Chen, Hailong
    Liu, Xinmin
    Bi, Lei
    Xiong, Jianghui
    Mao, Zebin
    Li, Yinghui
    NEUROCHEMICAL RESEARCH, 2010, 35 (09) : 1445 - 1454
  • [42] Xanomeline Protects Cortical Cells From Oxygen-Glucose Deprivation via Inhibiting Oxidative Stress and Apoptosis
    Xin, Rujuan
    Chen, Zhongjian
    Fu, Jin
    Shen, Fuming
    Zhu, Quangang
    Huang, Fang
    FRONTIERS IN PHYSIOLOGY, 2020, 11
  • [43] Extracellular dopamine induces the oxidative toxicity of SH-SY5Y cells
    Jiang, Yuhua
    Pei, Lin
    Li, Shupeng
    Wang, Min
    Liu, Fang
    SYNAPSE, 2008, 62 (11) : 797 - 803
  • [44] Antioxidant and Proliferative Activities of Bupleuri Radix Extract Against Serum Deprivation in SH-SY5Y Cells
    Seo, Mi Kyoung
    Cho, Hye Yeon
    Lee, Chan Hong
    Koo, Kyung Ah
    Park, Yong Ki
    Lee, Jung Goo
    Lee, Bong Ju
    Park, Sung Woo
    Kim, Young Hoon
    PSYCHIATRY INVESTIGATION, 2013, 10 (01) : 81 - 88
  • [45] Effects of uric acid on oxidative and nitrosative stress and other related parameters in SH-SY5Y human neuroblastoma cells.
    Marmol, Frederic
    Sanchez, Juan
    Martinez-Pinteno, Albert
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2021, 165
  • [46] Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules
    Motta, Jessica Rosso
    Jung, Ivo Emilio da Cruz
    Azzolin, Veronica Farina
    Teixeira, Cibele Ferreira
    Braun, Luiza Elizabete
    De Oliveira Nerys, Daniel Augusto
    Motano, Marco Aurelio Echart
    Duarte, Marta Maria Medeiros Frescura
    Maia-Ribeiro, Ednea Aguiar
    da Cruz, Ivana Beatrice Manica
    Barbisan, Fernanda
    JOURNAL OF FOOD BIOCHEMISTRY, 2021, 45 (02)
  • [47] Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death
    Fordel, Elke
    Thijs, Liesbet
    Martinet, Wim
    Lenjou, Marc
    Laufs, Tilmann
    Van Bockstaele, Dirk
    Moens, Luc
    Dewilde, Sylvia
    NEUROSCIENCE LETTERS, 2006, 410 (02) : 146 - 151
  • [48] Papaya epicarp extract protects against hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuronal cells
    Guizani, Nejib
    Waly, Mostafa I.
    Ali, Amanat
    Al-Saidi, Ghalib
    Singh, Vendita
    Bhatt, Neeru
    Rahman, Mohammad Shafiur
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 236 (10) : 1205 - 1210
  • [49] C3a Receptor Inhibition Protects Brain Endothelial Cells Against Oxygen-glucose Deprivation/Reperfusion
    Ahmad, Saif
    Kindelin, Adam
    Khan, Shah Alam
    Ahmed, Maaz
    Hoda, Md Nasrul
    Bhatia, Kanchan
    Ducruet, Andrew F.
    EXPERIMENTAL NEUROBIOLOGY, 2019, 28 (02) : 216 - 228
  • [50] Sesamin protects SH-SY5Y cells against mechanical stretch injury and promoting cell survival
    Zhiming Xu
    Yingliang Liu
    Dianxu Yang
    Fang Yuan
    Jun Ding
    Hao Chen
    Hengli Tian
    BMC Neuroscience, 18
12345