Cardiac contractility modulation therapy: molecular basis and rationale for use in models of systolic and diastolic heart failure

被引：0

作者：

Guarnaccia, Alberto ^{[1
]}

Dal Ferro, Matteo ^{[1
]}

Biffi, Mauro ^{[2
]}

Aspromonte, Nadia ^{[3
]}

Bongiorni, Maria Grazia ^{[4
]}

Clemenza, Francesco ^{[5
,8
]}

D'Onofrio, Antonio ^{[6
]}

Ferrari, Gaetano Maria De ^{[7
]}

Giallauria, Francesco

Grimaldi, Massimo ^{[9
]}

Matta, Mario ^{[7
]}

Marchese, Procolo ^{[10
]}

Occhetta, Eraldo ^{[11
]}

Oliva, Fabrizio ^{[12
]}

Porcari, Aldostefano ^{[1
]}

Rametta, Francesco ^{[11
]}

Senni, Michele ^{[13
]}

Tondo, Claudio ^{[14
]}

Ziacchi, Matteo ^{[2
]}

Sinagra, Gianfranco ^{[1
,15
,16
]}

机构：

[1] Azienda Sanit Univ Giuliano Isontina ASUGI, Ctr Diag & Cura Cardiomiopatie, Dipartimento Cardiovascolare, Trieste, Italy

[2] Azienda Osped Univ Bologna, Policlin St Orsola, Bologna, Italy

[3] Fdn Policlin Univ Agostino Gemelli, Dipartimento Sci Cardiovasc, IRCCS, Roma, TX USA

[4] Azienda Ospedaliero Univ, Osped Cisanello, Dipartimento Cardiovasc, UO Cardiol SSN 2, Pisa, Italy

[5] IRCCS ISMETT, Dipartimento Cardiotorac, Palermo, Italy

[6] Osped Monaldi, Dipartimento Cardiovasc, Naples, Italy

[7] Univ Torino, Osped Le Molinette, Dipartimento Cardiotoracovasc Citta Salute & Sci, Torino & Dipartimento Sci Med, Turin, Italy

[8] Univ Napoli Federico II, Dipartimento Sci Med Traslazionali, UO Med Interna Indirizzo Metab & Riabil, Naples, Italy

[9] Osped F Miulli, UOC Cardiol, Acquaviva Delle Fonti, BA, Italy

[10] Osped Mazzoni, Cardiol ASUR AV5, Ascoli Piceno, Italy

[11] Osped St Andrea, Dipartimento Cardiol, Vercelli, Italy

[12] ASST Grande Osped Metropolitano Niguarda, Dipartimento Cardiovasc, Milan, Italy

[13] ASST Papa Giovanni XXIII, Dipartimento Cardiovasc, Bergamo, Italy

[14] Univ Milan, IRCCS, Ctr Cardiol Monzino, Dipartimento Sci Biochim Chirurg & Odontoiatr, Milan, Italy

[15] Azienda Sanit Univ Giuliano Isontina ASUGI, Ctr Diag & Cura Cardiomiopatie, Dipartimento Cardiovasc, Via Valdoni 7, I-34149 Trieste, Italy

[16] Univ Trieste, Via Valdoni 7, I-34149 Trieste, Italy

来源：

GIORNALE ITALIANO DI CARDIOLOGIA | 2023年 / 24卷 / 08期

关键词：

Cardiac contractility modulation; Ejection fraction; Electrical therapy; Heart failure; Molecular mechanisms; ELECTRICAL SIGNALS; POSTEXTRASYSTOLIC POTENTIATION; CURRENTS; PROTEINS; DOGS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review illustrates the pathophysiological aspects and available scientific evidence on molecular mech-anisms about cardiac contractility modulation (CCM) therapy. The main advances in understanding the effect of this electrical therapy at cellular level in the heart are critically discussed in light of the data from clinical trials supporting the use of CCM therapy in patients with heart failure across a wide range of left ventricular ejection fraction values. This electrical therapy triggers a physiological cellular response leading to an improvement of cardiac performance and reverse ventricular remodeling, with no increase in oxygen consumption. The present review deals with the new potential applications of CCM for patients with chronic heart failure and paves the way for the development of a longitudinal Italian registry of patients implanted with this cardiac device.

引用

页码：646 / 652

页数：7

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