Pulmonary embolism and deep venous thrombosis after COVID-19: long-term risk in a population-based cohort study

被引：10

作者：

Sjoland, Helen ^{[7
]}

Lindgren, Martin ^{[1
,2
]}

Toska, Triantafyllia ^{[1
,2
]}

Hansson, Per-Olof ^{[1
,2
]}

Sandblad, Katarina Glise ^{[1
,2
]}

Alex, Christian ^{[2
]}

Bjorck, Lena ^{[1
,2
]}

Cronie, Ottmar ^{[3
]}

Bjork, Jonas ^{[4
,5
]}

Lundberg, Christina E. ^{[1
,6
]}

Adiels, Martin ^{[3
]}

Rosengren, Annika ^{[1
,2
]}

机构：

[1] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden

[2] Sahlgrens Univ Hosp, Ostra Hosp, Dept Med Geriatr & Emergency Med, Reg Vastra Gotaland, Gothenburg, Sweden

[3] Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Gothenburg, Sweden

[4] Lund Univ, Div Occupat & Environm Med, Lund, Sweden

[5] Skane Univ Hosp, Forum South, Clin Studies Sweden, Lund, Sweden

[6] Univ Gothenburg, Dept Food & Nutr & Sport Sci, Gothenburg, Sweden

[7] Sahlgrens Univ Hosp, Ostra Hosp, Sahlgrenska Acad, Dept Mol & Clin Med,Inst Med, Diagnosvagen 11, S-41685 Gothenburg, Sweden

来源：

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS | 2023年 / 7卷 / 05期

基金：

瑞典研究理事会;

关键词：

COVID-19; complications; thromboembolism; epidemiology; pulmonary embolism; venous; venous thrombosis; HEALTH-CARE WORKERS; ARTERIAL; DISEASE;

D O I：

10.1016/j.rpth.2023.100284

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Venous thromboembolism (VTE) (pulmonary embolism [PE] or deep venous thrombosis [DVT]) is common during acute COVID-19. Long-term excess risk has not yet been established. Objectives: To study long-term VTE risk after COVID-19. Methods: Swedish citizens aged 18 to 84 years hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), stratified by initial hospitalization, were compared to matched (1:5), nonexposed, population-derived subjects without COVID-19. Outcomes were incident VTE, PE, or DVT recorded within 60, 60 to <180, and & GE;180 days. Cox regression was used for evalu-ation, and a model adjusted for age, sex, comorbidities, and socioeconomic markers was developed to control for confounders. Results: Among exposed patients, 48,861 were hospitalized for COVID-19 (mean age, 60.6 years) and 894,121 were without hospitalization (mean age, 41.4 years). Among patients hospitalized for COVID-19, fully adjusted hazard ratios during 60 to <180 days were 6.05 (95% CI, 4.80-7.62) for PE and 3.97 (CI, 2.96-5.33) for DVT compared with that for nonexposed patients with corresponding estimates among those with COVID-19 without hospitalization 1.17 (CI, 1.01-1.35) and 0.99 (CI, 0.86-1.15), based on 475 and 2311 VTE events, respectively. Long-term (& GE;180 days) hazard ratios in patients hospitalized for COVID-19 were 2.01 (CI, 1.51-2.68) for PE and 1.46 (CI, 1.05-2.01) for DVT, while nonhospitalized patients had similar risk as nonexposed patients, based on 467 and 2030 VTE events, respectively. Conclusion: Patients hospitalized for COVID-19 retained an elevated excess risk of VTE, mainly PE, after 180 days, while long-term risk of VTE in individuals with COVID-19 without hospitalization was similar to that in the nonexposed patients.

引用

页数：14