Human leukocyte antigen and tumor immunotherapy (Review)

被引：13

作者：

Liu, Da-Hua ^{[1
]}

Mou, Fei-Fei ^{[2
]}

An, Min ^{[3
]}

Xia, Pu ^{[1
]}

机构：

[1] Jinzhou Med Univ, Biol Anthropol Inst, Coll Basic Med Sci, 40,Sect 3,Songpo Rd, Jinzhou 121001, Liaoning, Peoples R China

[2] Shijiazhuang Med Coll, Dept Nursing, Shijiazhuang 050599, Hebei, Peoples R China

[3] Jinzhou Cent Hosp, Dept Cardiol, Jinzhou 121001, Liaoning, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2023年 / 62卷 / 06期

基金：

中国国家自然科学基金;

关键词：

human leukocyte antigen; polymorphism; tumorigenesis; prognosis; immunotherapy; HLA CLASS-I; MHC CLASS-I; SQUAMOUS-CELL CARCINOMA; T-HELPER-CELLS; HEPATOCELLULAR-CARCINOMA; SUSCEPTIBILITY GENE; GASTRIC-CANCER; EXPRESSION; ASSOCIATION; MOLECULES;

D O I：

10.3892/ijo.2023.5516

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant tumors seriously endanger human health and life, and restrict economic development. Human leukocyte antigen (HLA) is the expression product of the human major histocompatibility complex, which, at present, is the most complex known polymorphic system. The polymorphism and expression of HLA molecules have been demonstrated to be associated with the occurrence and development of tumors. HLA molecules can regulate the proliferation of tumor cells and inhibit antitumor immunity. In the present review, the structure and function of HLA molecules, the polymorphism and expression of HLA in tumor tissue, the roles of HLA in tumor cells and tumor immunity, and the potential clinical application of HLA in tumor immunotherapy are summarized. The overall aim of the present review is to provide relevant information for the development of antitumor immunotherapies involving HLA in the clinic.

引用

页数：14

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