Design of One-for-All Near-Infrared Aggregation-Induced Emission Nanoaggregates for Boosting Theranostic Efficacy

被引:53
|
作者
Xie, Huilin [4 ]
Bi, Zhenyu [2 ]
Yin, Junli [1 ]
Li, Zeshun [2 ]
Hu, Lianrui [1 ]
Zhang, Chen [5 ]
Zhang, Jianquan [1 ]
Lam, Jacky W. Y. [1 ]
Zhang, Pengfei [6 ]
Kwok, Ryan T. K. [1 ]
Li, Kai [2 ]
Tang, Ben Zhong [3 ]
机构
[1] Hong Kong Univ Sci & Technol HKUST, Hong Kong Branch Chinese Natl Engn Res Ctr Tissue, Dept Chem, Div Life Sci, Hong Kong 999077, Peoples R China
[2] Southern Univ Sci & Technol SUSTech, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Guangdong, Peoples R China
[3] Hong Kong Univ Sci & Technol HKUST, Chinese Univ Hong Kong, South China Univ Technol SCUT, Shenzhen Inst Aggregate Sci & Technol, Hong Kong 999077, Guangdong 518172, Guangzhou 510640, Guangdong, Peoples R China
[4] Hong Kong Univ Sci & Technol HKUST, Hong Kong Branch Chinese Natl Engn Res Ctr Tissue, Dept Chem, Hong Kong 999077, Peoples R China
[5] Hong Kong Univ Sci & Technol HKUST, Southern Univ Sci & Technol SUSTech, Hong Kong Branch Chinese Natl Engn Res Ctr Tissue, Dept Chem, Hong Kong 999077, Guangdong, Peoples R China
[6] Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangdong Key Lab Nanomed, Shenzhen Engn Lab Nanomed & Nanoformulat, Shenzhen 518055, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
phototheranostics; aggregation-induced emission; near-infrared; fluorescence imaging; nanoaggregates; PHOTODYNAMIC THERAPY;
D O I
10.1021/acsnano.2c10661
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Fluorescence-guided phototherapy, including photodynamic and photothermal therapy, is considered an emerging noninvasive strategy for cancer treatments. Organic molecules are promising theranostic agents because of their facile construction, simple modification, and good biocompatibility. Organic systems that integrated multifunctionalities in a single component and achieved high efficiency in both imaging and therapies are rarely reported as the inherently competitive energy relaxation pathways are hard to modulate, and fluorescence quenching occurs upon molecular aggregation. Herein, a versatile theranostic platform with near-infrared emission, high fluorescence quantum yield, robust reactive oxygen species production, and excellent photothermal conversion efficiency was developed based on an aggregation-induced emission luminogen, namely, TPA-TBT. In vivo studies revealed that the TPA-TBT nanoaggregates exhibit outstanding photodynamic and photothermal therapy efficacy to ablate tumors inoculated in a mouse model. This work offers a design strategy to develop one-for-all cancer theranostic agents by modulating and utilizing the relaxation energy of excitons in full.
引用
收藏
页码:4591 / 4600
页数:10
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