Nanoparticles Bind to Endothelial Cells in Injured Blood Vessels via a Transient Protein Corona

被引：21

作者：

Lin, Zachary P. ^{[1
,2
]}

Ngo, Wayne ^{[1
,2
]}

Mladjenovic, Stefan M. ^{[1
,2
]}

Wu, Jamie L. Y. ^{[1
,2
]}

Chan, Warren C. W. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Toronto, Inst Biomed Engn, Toronto, ON M5S 3G9, Canada

[2] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5 3E1, Canada

[3] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada

[4] Univ Toronto, Dept Mat Sci & Engn, Toronto, ON M5S 1A1, Canada

[5] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

NANO LETTERS | 2023年 / 23卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Nanoparticles; Protein Corona; Platelet factor 4; Vessels; Endothelial cells; Delivery; LOW-DENSITY-LIPOPROTEIN; CHEMOKINE PLATELET-FACTOR-4; MODELS;

D O I：

10.1021/acs.nanolett.2c04501

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanoparticles travel through blood vessels to reach disease sites, but the local environment they encounter may affect their surface chemistry and cellular interactions. Here, we found that as nanoparticles transit through injured blood vessels they may interact with a highly localized concentration of platelet factor 4 proteins released from activated platelets. The platelet factor 4 binds to the nanoparticle surface and interacts with heparan sulfate proteoglycans on endothelial cells, and induces uptake. Understanding nanoparticle interactions with blood proteins and endothelial cells during circulation is critical to optimizing their design for diseased tissue targeting and delivery.

引用

页码：1003 / 1009

页数：7

共 50 条

[41] Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway
Huber, J
Boechzelt, H
Karten, B
Surboeck, M
Bochkov, VN
Binder, BR
Sattler, W
Leitinger, N
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (04) : 581 - 586
[42] Enhanced Gut-to-Liver Oral Drug Delivery via Ligand-Modified Nanoparticles by Attenuating Protein Corona Adsorption
Wang, Jie
Zhang, Zilong
Zhang, Zhuan
Zou, Zhiwen
Zhuo, Yan
Liu, Chang
Nie, Di
Gan, Yong
Yu, Miaorong
ACS Nano, 2024, 18 (52) : 35310 - 35324
[43] Characterization of protein corona formation on nanoparticles via the analysis of dynamic interfacial properties: Bovine serum albumin - silica particle interaction
Shourni, Sara
Javadi, Aliyar
Hosseinpour, Negahdar
Bahramian, Alireza
Raoufi, Mohammad
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2022, 638
[44] FORMATION OF NEW BLOOD VESSELS DURING GASTRIC ULCER HEALING. ROLE OF BONE MARROW DERIVED ENDOTHELIAL PROGENITOR CELLS
Ahluwalia, A.
Brzozowski, T.
Jones, M. K.
Ichikawa, Y.
Tarnawski, A. S.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2017, 68 (04): : 585 - 589
[45] Mechanism assay of interaction between blood vessels-near infrared probe and cell surface marker proteins of endothelial cells
Sisak, Muhammad Asri Abdul
Louis, Fiona
Miyao, Tomoyuki
Lee, Sun Hyeok
Chang, Young-Tae
Matsusaki, Michiya
MATERIALS TODAY BIO, 2022, 15
[46] LOCALIZATION OF NEUROPEPTIDE-Y AND ATRIAL-NATRIURETIC-PEPTIDE IN THE ENDOTHELIAL-CELLS OF HUMAN UMBILICAL BLOOD-VESSELS
CAI, WQ
BODIN, P
SEXTON, A
LOESCH, A
BURNSTOCK, G
CELL AND TISSUE RESEARCH, 1993, 272 (01) : 175 - 181
[47] MONOCLONAL-ANTIBODIES SPECIFIC FOR ENDOTHELIAL-CELLS OF MOUSE-BLOOD VESSELS - THEIR APPLICATION IN THE IDENTIFICATION OF ADULT AND EMBRYONIC ENDOTHELIUM
VECCHI, A
GARLANDA, C
LAMPUGNANI, MG
RESNATI, M
MATTEUCCI, C
STOPPACCIARO, A
SCHNURCH, H
RISAU, W
RUCO, L
MANTOVANI, A
DEJANA, E
EUROPEAN JOURNAL OF CELL BIOLOGY, 1994, 63 (02) : 247 - 254
[48] Biomimetic engineered nanoparticles target drug-resistant tumor cells and heterogeneous blood vessels for combination therapy of osteosarcoma
Yang, Wenbo
Cui, Yongzhi
Pan, Qing
Peng, Yizhong
Li, Kanglu
Huang, Wei
Zhang, Yan
Hu, Hongzhi
Shao, Zengwu
Zhang, Zhicai
CHEMICAL ENGINEERING JOURNAL, 2024, 485
[49] Electrical-Charge-Mediated Cancer Cell Targeting via Protein Corona-Decorated Superparamagnetic Nanoparticles in a Simulated Physiological Environment
Zhao, Jian
Wu, Shengming
Qin, Jingwen
Shi, Donglu
Wang, Yilong
ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (49) : 41986 - 41998
[50] DIFFERENT FORMS OF HUMAN VASCULAR ADHESION PROTEIN-1 (VAP-1) IN BLOOD-VESSELS IN-VIVO AND IN CULTURED ENDOTHELIAL-CELLS - IMPLICATIONS FOR LYMPHOCYTE-ENDOTHELIAL CELL-ADHESION MODELS
SALMI, M
JALKANEN, S
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (10) : 2803 - 2812

← 1 2 3 4 5 →