Nanoparticles Bind to Endothelial Cells in Injured Blood Vessels via a Transient Protein Corona

被引：21
|
作者：
Lin, Zachary P. [1 ,2 ]
Ngo, Wayne [1 ,2 ]
Mladjenovic, Stefan M. [1 ,2 ]
Wu, Jamie L. Y. [1 ,2 ]
Chan, Warren C. W. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Toronto, Inst Biomed Engn, Toronto, ON M5S 3G9, Canada
[2] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5 3E1, Canada
[3] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E5, Canada
[4] Univ Toronto, Dept Mat Sci & Engn, Toronto, ON M5S 1A1, Canada
[5] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
NANO LETTERS | 2023年 / 23卷 / 03期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Nanoparticles; Protein Corona; Platelet factor 4; Vessels; Endothelial cells; Delivery; LOW-DENSITY-LIPOPROTEIN; CHEMOKINE PLATELET-FACTOR-4; MODELS;
D O I：
10.1021/acs.nanolett.2c04501
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nanoparticles travel through blood vessels to reach disease sites, but the local environment they encounter may affect their surface chemistry and cellular interactions. Here, we found that as nanoparticles transit through injured blood vessels they may interact with a highly localized concentration of platelet factor 4 proteins released from activated platelets. The platelet factor 4 binds to the nanoparticle surface and interacts with heparan sulfate proteoglycans on endothelial cells, and induces uptake. Understanding nanoparticle interactions with blood proteins and endothelial cells during circulation is critical to optimizing their design for diseased tissue targeting and delivery.
引用
收藏
页码：1003 / 1009
页数：7
相关论文
共 50 条
  • [1] Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels
    Zhang, Yue
    Yang, Wan-Xi
    BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 2016, 7 : 675 - 684
  • [2] Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells
    Cui, Jiajia
    Qin, Lingfeng
    Zhang, Junwei
    Abrahimi, Parwiz
    Li, Hong
    Li, Guangxin
    Tietjen, Gregory T.
    Tellides, George
    Pober, Jordan S.
    Saltzman, W. Mark
    NATURE COMMUNICATIONS, 2017, 8
  • [3] Biological Behavior Regulation of Gold Nanoparticles via the Protein Corona
    Ma, Yu
    Hong, Jin
    Ding, Ya
    ADVANCED HEALTHCARE MATERIALS, 2020, 9 (06)
  • [4] The Development of Endothelial Cells in Revascularization of Blood Vessels in Kidney Scaffolds
    Du, Ao-Ling
    Liu, Dan
    Zhang, Wen-Hui
    Chen, Sheng-Hua
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2019, 9 (09) : 1167 - 1178
  • [5] Influence of protein corona on the interaction of glycogen-siRNA constructs with ex vivo human blood immune cells
    Wojnilowicz, Marcin
    Laznickova, Petra
    Ju, Yi
    Ang, Ching-Seng
    Tidu, Federico
    Bendickova, Kamila
    Forte, Giancarlo
    Plebanski, Magdalena
    Caruso, Frank
    Cavalieri, Francesca
    Fric, Jan
    BIOMATERIALS ADVANCES, 2022, 140
  • [6] The effect of polycarboxylate shell of magnetite nanoparticles on protein corona formation in blood plasma
    Szekeres, Marta
    Toth, Ildiko Y.
    Turcu, R.
    Tombacz, Etelka
    JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2017, 427 : 95 - 99
  • [7] Influence of Protein Corona on the Transport of Molecules into Cells by Mesoporous Silica Nanoparticles
    Paula, Amauri J.
    Araujo Junior, Roberto T.
    Martinez, Diego Stefani T.
    Paredes-Gamero, Edgar J.
    Nader, Helena B.
    Duran, Nelson
    Justo, Giselle Z.
    Alves, Oswaldo Luiz
    ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (17) : 8387 - 8393
  • [8] Protein corona on magnetite nanoparticles and internalization of nanoparticle–protein complexes into healthy and cancer cells
    Wen Jiang
    Kuilin Lai
    Yao Wu
    Zhongwei Gu
    Archives of Pharmacal Research, 2014, 37 : 129 - 141
  • [9] Interplay of protein corona and immune cells controls blood residency of liposomes
    Giulimondi, Francesca
    Digiacomo, Luca
    Pozzi, Daniela
    Palchetti, Sara
    Vulpis, Elisabetta
    Capriotti, Anna Laura
    Chiozzi, Riccardo Zenezini
    Lagana, Aldo
    Amenitsch, Heinz
    Masuelli, Laura
    Mahmoudi, Morteza
    Screpanti, Isabella
    Zingoni, Alessandra
    Caracciolo, Giulio
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [10] Fluorescent imaging of endothelial cells in bioengineered blood vessels: the impact of crosslinking of the scaffold
    Niu, Guoguang
    Sapoznik, Etai
    Lu, Peng
    Criswell, Tracy
    Mohs, Aaron M.
    Wang, Ge
    Lee, Sang-Jin
    Xu, Yong
    Soker, Shay
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2016, 10 (11) : 955 - 966
12345