The significance of osteosarcopenia as a predictor of the long-term outcomes in hepatocellular carcinoma after hepatic resection

被引:17
|
作者
Yanagaki, Mitsuru [1 ]
Haruki, Koichiro [1 ]
Taniai, Tomohiko [1 ]
Igarashi, Yosuke [1 ]
Yasuda, Jungo [1 ]
Furukawa, Kenei [1 ]
Onda, Shinji [1 ]
Shirai, Yoshihiro [1 ]
Tsunematsu, Masashi [1 ]
Ikegami, Toru [1 ]
机构
[1] Jikei Univ, Div Hepatobiliary & Pancreat Surg, Sch Med, Dept Surg, Tokyo, Japan
基金
日本学术振兴会;
关键词
hepatic resection; hepatocellular carcinoma; osteosarcopenia; prognostic factor; sarcopenia; BONE-MINERAL DENSITY; NUTRITIONAL-STATUS; LYMPHOCYTE RATIO; SARCOPENIA; CLASSIFICATION; SURVIVAL; IMPACT; CANCER; INDEX;
D O I
10.1002/jhbp.1246
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Frailty, represented by sarcopenia and osteopenia, has been associated with worse survival after hepatectomy in patients with hepatocellular carcinoma. Recently, the concept and term "osteosarcopenia" have been proposed, which has been associated with worse outcome in several malignancies. Methods This study included 227 patients who underwent elective hepatic resection for hepatocellular carcinoma. Osteopenia was evaluated with computed tomographic measurement of pixel density in the midvertebral core of the 11th thoracic vertebra. The skeletal muscle index (SMI) was evaluated with psoas muscle areas at the third lumbar vertebra. Osteosarcopenia was defined as the concomitant occurrence of osteopenia and low SMI. We retrospectively investigated the relationship between osteosarcopenia and disease-free and overall survival. Results Osteosarcopenia was identified in 27 (12%) of the patients. Multivariate analysis showed that osteosarcopenia (P < .001), C-reactive protein-to-albumin ratio >= 0.02 (P = .002), and stage >= III (P <= .001) were independent predictors of disease-free survival, while osteosarcopenia (P < .001), Child-Pugh grade B (P = .002), C-reactive protein-to-albumin ratio >= 0.02 (P = .001), low SMI (P <= .001), and stage >= III (P <= .001) were independent predictors of overall survival. Conclusion Preoperative osteosarcopenia may be a prognostic factor in patients with hepatocellular carcinoma after hepatic resection. Our results suggests that the preoperative maintenance of skeletal muscle and bone density may potentially improve prognosis.
引用
收藏
页码:453 / 461
页数:9
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