Pharmacological Interpretation of the Efficacy of Ensifentrine in Chronic Obstructive Pulmonary Disease: Insights from ENHANCE Trials

被引:3
作者
Calzetta, Luigino [1 ]
Cazzola, Mario [2 ]
Rogliani, Paola [2 ]
机构
[1] Univ Parma, Dept Med & Surg, Resp Dis & Lung Funct Unit, Parma, Italy
[2] Univ Roma Tor Vergata, Dept Expt Med, Unit Resp Med, Rome, Italy
关键词
GLYCOPYRRONIUM; INDACATEROL;
D O I
10.1164/rccm.202308-1355LE
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:224 / 225
页数:3
相关论文
共 6 条
[1]   Ensifentrine, a Novel Phosphodiesterase 3 and 4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease Randomized, Double-Blind, Placebo-controlled, Multicenter Phase III Trials (the ENHANCE Trials) [J].
Anzueto, Antonio ;
Barjaktarevic, Igor Z. ;
Siler, Thomas M. ;
Rheault, Tara ;
Bengtsson, Thomas ;
Rickard, Kathleen ;
Sciurba, Frank .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 208 (04) :406-416
[2]   Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to approval [J].
Calzetta, Luigino ;
Pistocchini, Elena ;
Chetta, Alfredo ;
Rogliani, Paola ;
Cazzola, Mario .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2023, 32 (06) :525-536
[3]   Advances in targeting cyclic nucleotide phosphodiesterases [J].
Maurice, Donald H. ;
Ke, Hengming ;
Ahmad, Faiyaz ;
Wang, Yousheng ;
Chung, Jay ;
Manganiello, Vincent C. .
NATURE REVIEWS DRUG DISCOVERY, 2014, 13 (04) :290-314
[4]   Roflumilast -: an oral anti-inflammatory treatment for chronic obstructive pulmonary disease:: a randomised controlled trial [J].
Rabe, KF ;
Bateman, ED ;
O'Donnell, D ;
Witte, S ;
Bredenbröker, D ;
Bethke, TD .
LANCET, 2005, 366 (9485) :563-571
[5]   Indacaterol, glycopyrronium, and mometasone: Pharmacological interaction and anti-inflammatory profile in hyperresponsive airways [J].
Rogliani, Paola ;
Ritondo, Beatrice Ludovica ;
Facciolo, Francesco ;
Matera, Maria Gabriella ;
Nikolaev, Ivan ;
Calzetta, Luigino .
PHARMACOLOGICAL RESEARCH, 2021, 172
[6]   Indacaterol-Glycopyrronium versus Salmeterol-Fluticasone for COPD [J].
Wedzicha, Jadwiga A. ;
Banerji, Donald ;
Chapman, Kenneth R. ;
Vestbo, Jorgen ;
Roche, Nicolas ;
Ayers, Timothy ;
Thach, Chau ;
Fogel, Robert ;
Patalano, Francesco ;
Vogelmeier, Claus F. .
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (23) :2222-2234