Birefringence-derived artifact in optical coherence tomography imaging of the lamina cribrosa in eyes with glaucoma

被引：2

作者：

Miura, Masahiro ^{[1
]}

Makita, Shuichi ^{[2
]}

Yasuno, Yoshiaki ^{[2
]}

Nakagawa, Hayate ^{[1
]}

Azuma, Shinnosuke ^{[3
]}

Mino, Toshihiro ^{[3
]}

Miki, Atsuya ^{[4
]}

机构：

[1] Tokyo Med Univ, Ibaraki Med Ctr, Dept Ophthalmol, 3-20-1 Chuo, Inashiki, Ibaraki 300395, Japan

[2] Univ Tsukuba, Computat Opt Grp, Tsukuba, Ibaraki, Japan

[3] Topcon Corp, Tokyo, Japan

[4] Aichi Med Univ, Dept Myopia Control Res, Nagakude, Japan

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

POSTERIOR EYE; DEFECTS; IMAGES;

D O I：

10.1038/s41598-023-43820-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated birefringence-derived artifacts that potentially mimic focal defects of the lamina cribrosa (focal LC defects) in optical coherence tomography (OCT) imaging of eyes with glaucoma. This study included 74 eyes of 48 patients with glaucoma. Five horizontal line B-scan images of the optic disc were obtained using commercial swept-source OCT. From a dataset of prototype swept-source polarization-diversity OCT, we calculated the following types of OCT images: polarization-dependent, polarization-dependent attenuation-coefficient, polarization-independent, and polarization-independent attenuation-coefficient. We assessed the commercial OCT images for the presence of birefringence-derived artifacts by comparison with the polarization-diversity OCT images. Commercial OCT showed suggestive findings of focal LC defects in 17 of 74 eyes. Reevaluation using polarization-independent OCT revealed that the focal LC defects in one of 17 eyes (5.9%) were actually birefringence-derived artifacts. This study demonstrated the existence of birefringence-derived artifacts mimicking focal LC defects in commercial OCT imaging and indicated that polarization-diversity OCT is an effective tool to evaluate the presence of these artifacts.

引用

页数：8

共 28 条

[21] Depth-resolved model-based reconstruction of attenuation coefficients in optical coherence tomography
Vermeer, K. A.
Mo, J.
Weda, J. J. A.
Lemij, H. G.
de Boer, J. F.
[J]. BIOMEDICAL OPTICS EXPRESS, 2014, 5 (01): : 322 - 337
[22] Polarization management to mitigate misalignment-induced fringe fading in fiber-based optical coherence tomography
Wang, Nanshuo
Liu, Xinyu
Xiong, Qiaozhou
Xie, Jun
Chen, Shi
Liu, Linbo
[J]. OPTICS LETTERS, 2017, 42 (15) : 2996 - 2999
[23] Scleral structure, organisation and disease. A review
Watson, PG
Young, RD
[J]. EXPERIMENTAL EYE RESEARCH, 2004, 78 (03) : 609 - 623
[24] In Vivo 3D Determination of Peripapillary Scleral and Retinal Layer Architecture Using Polarization-Sensitive Optical Coherence Tomography
Willemse, Joy
Graefe, Maximilian G. O.
Verbraak, Frank D.
de Boer, Johannes F.
[J]. TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2020, 9 (11): : 1 - 8
[25] Optical Rheology of Porcine Sclera by Birefringence Imaging
Yamanari, Masahiro
Ishii, Kotaro
Fukuda, Shinichi
Lim, Yiheng
Duan, Lian
Makita, Shuichi
Miura, Masahiro
Oshika, Tetsuro
Yasuno, Yoshiaki
[J]. PLOS ONE, 2012, 7 (09):
[26] Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1-μm probe
Yamanari, Masahiro
Lim, Yiheng
Makita, Shuichi
Yasuno, Yoshiaki
[J]. OPTICS EXPRESS, 2009, 17 (15): : 12385 - 12396
[27] Visibility of trabecular meshwork by standard and polarization-sensitive optical coherence tomography
Yasuno, Yoshiaki
Yamanari, Masahiro
Kawana, Keisuke
Miura, Masahiro
Fukuda, Shinichi
Makita, Shuichi
Sakai, Shingo
Oshika, Tetsuro
[J]. JOURNAL OF BIOMEDICAL OPTICS, 2010, 15 (06)
[28] Focal Lamina Cribrosa Defects Associated With Glaucomatous Rim Thinning and Acquired Pits
You, Jae Young
Park, Sung Chul
Su, Daniel
Teng, Christopher C.
Liebmann, Jeffrey M.
Ritch, Robert
[J]. JAMA OPHTHALMOLOGY, 2013, 131 (03) : 314 - 320

← 1 2 3 →