Circular RNAs: Diagnostic and Therapeutic Perspectives in CNS Diseases

被引：1

作者：

Bai, Ying ^{[1
]}

Yao, Hong-hong ^{[1
,2
,3
]}

机构：

[1] Southeast Univ, Sch Med, Dept Pharmacol, Jiangsu Prov Key Lab Crit Care Med, Nanjing 210009, Peoples R China

[2] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China

[3] Southeast Univ, Inst Life Sci, Key Lab Dev Genes & Human Dis, Nanjing 210009, Peoples R China

来源：

CURRENT MEDICAL SCIENCE | 2023年 / 43卷 / 05期

基金：

中国国家自然科学基金;

关键词：

circular RNAs; brain; central nervous system disease; diagnosis; therapy; DIFFERENTIALLY EXPRESSED PROFILES; SUDDEN UNEXPECTED DEATH; ISCHEMIC-STROKE; NONCODING RNAS; CELL APOPTOSIS; BRAIN; AUTOPHAGY; INJURY; MECHANISMS; BIOMARKERS;

D O I：

10.1007/s11596-023-2784-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Circular RNAs (circRNAs) are a class of regulatory non-coding RNAs characterized by the presence of covalently closed ends. A growing body of evidence suggests that circRNAs play important roles in physiology and pathology. In particular, accumulating data on circRNA functions in various central nervous system (CNS) diseases and their correlations indicate that circRNAs are critical contributors to the onset and development of brain disorders. In this review, we focus on the regulatory and functional roles of circRNAs in CNS diseases, highlighting their diagnostic and therapeutic potential, with the aim of providing new insights into CNS diseases.

引用

页码：879 / 889

页数：11

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