New Insight into the Potential Protective Function of Sulforaphene against ROS-Mediated Oxidative Stress Damage In Vitro and In Vivo

被引:7
|
作者
Zhang, Bo [1 ]
Liu, Pengtao [1 ]
Sheng, Huakang [1 ]
Guo, Yang [1 ]
Han, Yongzhi [1 ]
Suo, Lin [1 ]
Yuan, Qipeng [1 ]
机构
[1] Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
基金
中国国家自然科学基金;
关键词
sulforaphene; oxidative damage; inflammation; Nrf2; anti-aging; INDUCED LIVER; FREE-RADICALS; RADISH SEEDS; APOPTOSIS; MECHANISMS; CANCER; CELLS; BRAIN; NRF2; ISOTHIOCYANATES;
D O I
10.3390/ijms241713129
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sulforaphene (SFE) is a kind of isothiocyanate isolated from radish seeds that can prevent free-radical-induced diseases. In this study, we investigated the protective effect of SFE on oxidative-stress-induced damage and its molecular mechanism in vitro and in vivo. The results of cell experiments show that SFE can alleviate D-gal-induced cytotoxicity, promote cell cycle transformation by inhibiting the production of reactive oxygen species (ROS) and cell apoptosis, and show a protective effect on cells with H2O2-induced oxidative damage. Furthermore, the results of mice experiments show that SFE can alleviate D-galactose-induced kidney damage by inhibiting ROS, malondialdehyde (MDA), and 4-hydroxyalkenals (4-HNE) production; protect the kidney against oxidative stress-induced damage by increasing antioxidant enzyme activity and upregulating the Nrf2 signaling pathway; and inhibit the activity of pro-inflammatory factors by downregulating the expression of Toll-like receptor 4 (TLR4)-mediated inflammatory response. In conclusion, this research shows that SFE has antioxidant effects, providing a new perspective for studying the anti-aging properties of natural compounds.
引用
收藏
页数:20
相关论文
共 50 条
  • [11] Evaluating the protective effect of metformin against diclofenac-induced oxidative stress and hepatic damage: In vitro and in vivo studies
    Darijani, Mohammad Hossein
    Aminzadeh, Azadeh
    Rahimi, Hamid-Reza
    Mandegary, Ali
    Heidari, Mahmoud-Reza
    Karami-Mohajeri, Somayyeh
    Jafari, Elham
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 685
  • [12] Haloperidol is neuroprotective against oxidative-stress related damage in vitro and in vivo
    Schetz, JA
    Perez, E
    Yang, SH
    Simpkins, J
    FASEB JOURNAL, 2005, 19 (05): : A1080 - A1080
  • [13] Protective effect of deferoxamine, as a potential anti-inflammatory chemical, on ROS-mediated cell and DNA damage in chemiluminescence systems
    Mehrzad, Jalil
    Chaichi, Mohammad Javad
    Nazari, O.
    Ehtesham, A.
    Parvar, M.
    Hosseinkhani, S.
    Golchoubian, H.
    Schuberth, H. J.
    LUMINESCENCE, 2014, 29 : 30 - 30
  • [14] Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo
    Shi, Gui-Fang
    An, Li-Jia
    Jiang, Bo
    Guan, Shui
    Bao, Yong-Ming
    NEUROSCIENCE LETTERS, 2006, 403 (03) : 206 - 210
  • [15] Protective Effects of Extracts from Fructus rhodomyrti against Oxidative DNA Damage In Vitro and In Vivo
    Ke, Yuebin
    Xu, Xinyun
    Wu, Shuang
    Huang, Juan
    Geng, Yijie
    Misra, Hara
    Li, Yunbo
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, 2013
  • [16] Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models
    Shashank Kumar
    Amita Mishra
    Abhay K Pandey
    BMC Complementary and Alternative Medicine, 13
  • [17] Antioxidant mediated protective effect of Parthenium hysterophorus against oxidative damage using in vitro models
    Kumar, Shashank
    Mishra, Amita
    Pandey, Abhay K.
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 13
  • [18] Protective effect of the methanolic extract from Duchesnea indica against oxidative stress in vitro and in vivo
    Hu, Weicheng
    Han, Woong
    Huang, Chaoqing
    Wang, Myeong-Hyeon
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2011, 31 (01) : 42 - 50
  • [19] Antioxidant Potential of Sulfated Polysaccharides from Padina boryana; Protective Effect against Oxidative Stress in In Vitro and In Vivo Zebrafish Model
    Jayawardena, Thilina U.
    Wang, Lei
    Sanjeewa, K. K. Asanka
    Kang, Sang In
    Lee, Jung-Suck
    Jeon, You-Jin
    MARINE DRUGS, 2020, 18 (04)
  • [20] Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro
    Hu, Lihua
    Li, Lingrui
    Xu, Demei
    Xia, Xiaomin
    Pi, Ruxian
    Xu, Duo
    Wang, Wenchao
    Du, Hong
    Song, Erqun
    Song, Yang
    CHEMICO-BIOLOGICAL INTERACTIONS, 2014, 213 : 51 - 59