A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation

被引：68

作者：

Supuran, Claudiu T. ^{[1
]}

机构：

[1] Univ Florence, Neurofarba Dept, Sect Pharmaceut Sci, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Florence, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2023年 / 93卷

关键词：

Carbonic anhydrase; Drug design; Inhibitor; Activator; Inhibition/activation mechanisms; Anticancer agent; Antiobesity drug; Antiinfectives; Cognitive disorders; Sulfonamide; Coumarin; SLC-0111; BETA-CLASS ENZYME; PRESSURE-LOWERING AGENTS; MITOCHONDRIAL ISOZYME-V; YEAST SACCHAROMYCES-CEREVISIAE; PATHOGENS CANDIDA-ALBICANS; TARGETING TUMOR HYPOXIA; RAY CRYSTAL-STRUCTURES; 12 MAMMALIAN ISOFORMS; IN-VIVO SELECTIVITY; HCA IX INHIBITORS;

D O I：

10.1016/j.bmcl.2023.129411

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Advances in the carbonic anhydrase (CA, EC 4.2.1.1) research over the last three decades are presented, with an emphasis on the deciphering of the activation mechanism, the development of isoform-selective inhibitors/ activators by the tail approach and their applications in the management of obesity, hypoxic tumors, neurological conditions, and as antiinfectives.

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页数：26

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