A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation

被引：68

作者：

Supuran, Claudiu T. ^{[1
]}

机构：

[1] Univ Florence, Neurofarba Dept, Sect Pharmaceut Sci, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Florence, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2023年 / 93卷

关键词：

Carbonic anhydrase; Drug design; Inhibitor; Activator; Inhibition/activation mechanisms; Anticancer agent; Antiobesity drug; Antiinfectives; Cognitive disorders; Sulfonamide; Coumarin; SLC-0111; BETA-CLASS ENZYME; PRESSURE-LOWERING AGENTS; MITOCHONDRIAL ISOZYME-V; YEAST SACCHAROMYCES-CEREVISIAE; PATHOGENS CANDIDA-ALBICANS; TARGETING TUMOR HYPOXIA; RAY CRYSTAL-STRUCTURES; 12 MAMMALIAN ISOFORMS; IN-VIVO SELECTIVITY; HCA IX INHIBITORS;

D O I：

10.1016/j.bmcl.2023.129411

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Advances in the carbonic anhydrase (CA, EC 4.2.1.1) research over the last three decades are presented, with an emphasis on the deciphering of the activation mechanism, the development of isoform-selective inhibitors/ activators by the tail approach and their applications in the management of obesity, hypoxic tumors, neurological conditions, and as antiinfectives.

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页数：26

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共 520 条

[1] Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: Role of hydrogen-bonding networks in ligand binding and drug design [J].

Abbate, F ;

Supuran, CT ;

Scozzafava, A ;

Orioli, P ;

Stubbs, MT ;

Klebe, G .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (17) :3583-3587

[2] Dominant behaviours in the expression of human carbonic anhydrase hCA I activity [J].

Abdelrahim, M. Yahia M. ;

Tanc, Muhammet ;

Winum, Jean-Yves ;

Supuran, Claudiu T. ;

Barboiu, Mihail .

CHEMICAL COMMUNICATIONS, 2014, 50 (59) :8043-8046

[3] 2-((1H-Benzo[d]imidazol-2-yl)amino)benzo[d]thiazole-6-sulphonamides: a class of carbonic anhydrase II and VII-selective inhibitors [J].

Abdoli, Morteza ;

Supuran, Claudiu T. ;

Zalubovskis, Raivis .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 38 (01)

[4] Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors [J].

Abdoli, Morteza ;

Bonardi, Alessandro ;

Supuran, Claudiu T. ;

Zalubovskis, Raivis .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 38 (01)

[5] 4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors [J].

Abdoli, Morteza ;

Bonardi, Alessandro ;

Supuran, Claudiu T. ;

Zalubovskis, Raivis .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 38 (01) :156-165

[6] Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies [J].

Abo-Ashour, Mahmoud F. ;

Eldehna, Wagdy M. ;

Nocentini, Alessio ;

Ibrahim, Hany S. ;

Bua, Silvia ;

Abdel-Aziz, Hatem A. ;

Abou-Seri, Sahar M. ;

Supuran, Claudiu T. .

BIOORGANIC CHEMISTRY, 2019, 87 :794-802

[7] Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids [J].

Aboukhatwa, Shaimaa M. ;

Sidhom, Peter A. ;

Angeli, Andrea ;

Supuran, Claudiu T. ;

Tawfik, Haytham O. .

ACS OMEGA, 2023, :7666-7683

[8] Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae [J].

Abutaleb, Nader S. ;

Elhassanny, Ahmed E. M. ;

Nocentini, Alessio ;

Hewitt, Chad S. ;

Elkashif, Ahmed ;

Cooper, Bruce R. ;

Supuran, Claudiu T. ;

Seleem, Mohamed N. ;

Flaherty, Daniel P. .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 37 (01) :51-61

[9] Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review [J].

Aggarwal, Mayank ;

Kondeti, Bhargav ;

McKenna, Robert .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2013, 23 (06) :717-724

[10] In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives [J].

Ahlskog, Julia K. J. ;

Dumelin, Christoph E. ;

Truessel, Sabrina ;

Marlind, Jessica ;

Neri, Dario .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (16) :4851-4856

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