The ratio of monocyte count and high-density lipoprotein cholesterol mediates the association between urinary tungsten and cardiovascular disease: a study from NHANES 2005-2018

被引：7

作者：

Wu, Yudong ^{[1
,2
]}

Meng, Yajie ^{[3
]}

Yi, Weizhuo ^{[1
,2
]}

Pan, Rubing ^{[1
,2
]}

Liang, Yunfeng ^{[1
,2
]}

Li, Yuxuan ^{[1
,2
]}

Jin, Xiaoyu ^{[1
,2
]}

Sun, Xiaoni ^{[1
,2
]}

Yan, Shuangshuang ^{[1
,2
]}

Mei, Lu ^{[1
,2
]}

Song, Jian ^{[1
,2
]}

Song, Shasha ^{[1
,2
]}

Cheng, Jian ^{[1
,2
]}

Su, Hong ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China

[2] Anhui Prov Key Lab Major Autoimmune Dis, Hefei 230032, Anhui, Peoples R China

[3] Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 211112, Jiangsu, Peoples R China

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2023年 / 30卷 / 36期

基金：

中国国家自然科学基金;

关键词：

Urinary tungsten; MHR; Cardiovascular disease; NHANES; RCS; Mediation analysis; HIGH BLOOD-PRESSURE; DNA METHYLATION; HEAVY-METALS;

D O I：

10.1007/s11356-023-28214-4

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Tungsten (W) is an emerging contaminant that can damage multiple systems in humans. However, studies of its effects on cardiovascular disease (CVD) are limited. The monocyte count to high-density lipoprotein cholesterol ratio (MHR) is a composite inflammatory index of great concern in recent years, derived from lipid and cell inflammation parameters, that is used to indicate the risk of CVD. This study aimed to investigate the association between urinary W and CVD in the general population and compare the mediating effects of lipids, cell inflammatory parameters, and MHR to find a better target for intervention. We analyzed data from 9137 (& GE; 20 years) participants in the National Health and Nutrition Examination Survey (NHANES), from 2005 to 2018. Restricted cubic splines (RCS) and survey-weighted generalized linear models (SWGLMs) were used to assess the relationship between W and CVD. Mediated analyses were used to explore lipids, cell inflammatory parameters, and MHR in the possible mediating pathways between W and CVD. In SWGLM, we found that W enhances the risk of CVD, especially congestive heart failure (CHF), coronary heart disease (CHD), and angina pectoris (AP). Women, higher age groups (& GE; 55 years), and those with hypertension were vulnerable to W in the subgroup analysis. Mediation analysis showed that monocyte count (MC), white blood cell count (WBC), high-density lipoprotein cholesterol (HDL), and MHR played a mediating role between W and CVD in proportions of 8.49%, 3.70%, 5.18%, and 12.95%, respectively. In conclusion, our study shows that urinary W can increase the risk of CVD, especially for CHF, CHD, and AP. Women, older age groups, and people with hypertension seem to be more vulnerable to W. In addition, MC, WBC, HDL, and MHR mediated the association between W and CVD, especially MHR, which suggests that we should consider it as a priority intervention target in the future.

引用

页码：85930 / 85939

页数：10

共 46 条

[1] Heavy Metals and Cardiovascular Disease: Results from the National Health and Nutrition Examination Survey (NHANES) 1999-2006 [J].