Effect of Catheter Ablation for Atrial Fibrillation in Heart Failure With Mid-Range or Preserved Ejection Fraction-Pooled Analysis of the AF Frontier Ablation Registry and Hokuriku-Plus AF Registry

被引：8

作者：

Tsuda, Toyonobu ^{[1
]}

Kato, Takeshi ^{[1
]}

Usuda, Keisuke ^{[2
]}

Kusayama, Takashi ^{[1
]}

Usui, Soichiro ^{[1
]}

Sakata, Kenji ^{[1
]}

Hayashi, Kenshi ^{[1
]}

Kawashiri, Masa-aki ^{[3
]}

Yamagishi, Masakazu ^{[4
]}

Takamura, Masayuki ^{[1
]}

Otsuka, Takayuki ^{[5
]}

Suzuki, Shinya ^{[5
]}

Hirata, Akio ^{[6
]}

Murakami, Masato ^{[7
]}

Takami, Mitsuru ^{[8
]}

Kimura, Masaomi ^{[9
]}

Fukaya, Hidehira ^{[10
]}

Nakahara, Shiro ^{[11
]}

Shimizu, Wataru ^{[12
]}

Iwasaki, Yu-ki ^{[12
]}

Hayashi, Hiroshi ^{[12
]}

Harada, Tomoo ^{[13
]}

Nakajima, Ikutaro ^{[13
]}

Okumura, Ken ^{[14
]}

Koyama, Junjiroh ^{[14
]}

Tokuda, Michifumi ^{[15
]}

Yamane, Teiichi ^{[15
]}

Momiyama, Yukihiko ^{[16
]}

Tanimoto, Kojiro ^{[16
]}

Soejima, Kyoko ^{[17
]}

Nonoguchi, Noriko ^{[17
]}

Ejima, Koichiro ^{[18
]}

Hagiwara, Nobuhisa ^{[18
]}

Harada, Masahide ^{[19
]}

Sonoda, Kazumasa ^{[20
]}

Inoue, Masaru ^{[2
]}

Kumagai, Koji ^{[21
]}

Hayashi, Hidemori ^{[22
]}

Satomi, Kazuhiro ^{[23
]}

Yazaki, Yoshinao ^{[23
]}

Watari, Yuji ^{[24
]}

Arai, Masaru ^{[25
]}

Watanabe, Ryuta ^{[25
]}

Yokoyama, Katsuaki ^{[25
,26
]}

Matsumoto, Naoya ^{[26
]}

Nagashima, Koichi

Okumura, Yasuo ^{[25
]}

机构：

[1] Kanazawa Univ, Dept Cardiovasc Med, Grad Sch Med Sci, Kanazawa, Japan

[2] Ishikawa Prefectural Cent Hosp, Kanazawa, Japan

[3] Kaga Med Ctr, Kaga, Japan

[4] Osaka Univ Human Sci, Settsu, Japan

[5] Cardiovasc Inst, Dept Cardiol, Tokyo, Japan

[6] Osaka Police Hosp, Cardiovasc Div, Osaka, Japan

[7] Shonan Kamakura Gen Hosp, Div Cardiol, Kamakura, Japan

[8] Saiseikai Nakatsu Hosp, Osaka, Japan

[9] Hirosaki Univ, Div Cardiol Pulm Med & Nephrol, Sch Med, Hirosaki, Japan

[10] Kitasato Univ Hosp, Sagamihara, Japan

[11] Dokkyo Med Univ, Saitama Med Ctr, Koshigaya, Japan

[12] Nippon Med Hosp, Tokyo, Japan

[13] St Marianna Univ, Sch Med Hosp, Kawasaki, Japan

[14] Saiseikai Kumamoto Hosp, Kumamoto, Japan

[15] Tokyo Jikei Univ, Sch Med Hosp, Tokyo, Japan

[16] Natl Hosp Org Tokyo Med Ctr, Tokyo, Japan

[17] Kyorin Univ Hosp, Tokyo, Japan

[18] Tokyo Womens Med Univ Hosp, Tokyo, Japan

[19] Fujita Univ Hlth Hosp, Toyoake, Japan

[20] Tokyo Rinkai Hosp, Tokyo, Japan

[21] Gunma Cardiovasc Ctr, Maebashi, Japan

[22] Juntendo Univ, Tokyo, Japan

[23] Tokyo Med Univ Hosp, Tokyo, Japan

[24] Teikyo Univ, Tokyo, Japan

[25] Nihon Univ Itabashi Hosp, Div Cardiol, Tokyo, Japan

[26] Nihon Univ Hosp, Dept Cardiol, Tokyo, Japan

来源：

CIRCULATION JOURNAL | 2023年 / 87卷 / 07期

关键词：

Atrial fibrillation; Cardiovascular death; Catheter ablation; Heart failure; RISK-FACTOR; RECURRENCE; STROKE;

D O I：

10.1253/circj.CJ-22-0461

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: A recent randomized trial demonstrated that catheter ablation for atrial fibrillation (AF) in patients with heart failure with reduced ejection fraction (EF) is associated with a reduction in death or heart failure. However, the effect of catheter ablation for AF in patients with heart failure with mid-range or preserved EF is unclear.Methods and Results: We screened 899 AF patients (72.4% male, mean age 68.4 years) with heart failure and left ventricular EF & GE;40% from 2 Japanese multicenter AF registries: the Atrial Fibrillation registry to Follow the long-teRm Outcomes and use of aNTI-coagulants aftER Ablation (AF Frontier Ablation Registry) as the ablation group (525 patients who underwent ablation) and the Hokuriku-Plus AF Registry as the medical therapy group (374 patients who did not undergo ablation). Propensity score matching was performed in these 2 registries to yield 106 matched patient pairs. The primary endpoint was a composite of cardiovascular death and hospitalization for heart failure. At 24.6 months, the ablation group had a significantly lower incidence of the primary end-point (hazard ratio 0.32; 95% confidence interval 0.13-0.70; P=0.004) than the medical therapy group.Conclusions: Compared with medical therapy, catheter ablation for AF in patients with heart failure and mid-range or preserved EF was associated with a significantly lower incidence of cardiovascular death or hospitalization for heart failure.

引用

页码：939 / +

页数：11

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