L-Theanine and Immunity: A Review

被引：14
作者：
Chen, Shuna [1 ]
Kang, Jiaxin [1 ]
Zhu, Huanqing [1 ]
Wang, Kaixi [1 ]
Han, Ziyi [1 ]
Wang, Leyu [1 ]
Liu, Junsheng [1 ]
Wu, Yuanyuan [1 ]
He, Puming [1 ]
Tu, Youying [1 ]
Li, Bo [1 ]
机构：
[1] Zhejiang Univ, Dept Tea Sci, Hangzhou 310058, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 09期
基金：
中国国家自然科学基金;
关键词：
L-theanine; immunoregulation; mechanism; application; KAPPA-B PATHWAYS; AMINO-ACIDS; L-CYSTINE; INDUCED NEUROTOXICITY; GROWTH-PERFORMANCE; ANTITUMOR-ACTIVITY; DOWN-REGULATION; TUMOR-GROWTH; CELLS; TEA;
D O I：
10.3390/molecules28093846
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
L-theanine (N-ethyl-?-glutamine) is the main amino acid in tea leaves. It not only contributes to tea flavor but also possesses several health benefits. Compared with its sedative and calming activities, the immunomodulatory effects of L-theanine have received less attention. Clinical and epidemiological studies have shown that L-theanine reduces immunosuppression caused by strenuous exercise and prevents colds and influenza by improving immunity. Numerous cell and animal studies have proven that theanine plays an immunoregulatory role in inflammation, nerve damage, the intestinal tract, and tumors by regulating ?dT lymphocyte function, glutathione (GSH) synthesis, and the secretion of cytokines and neurotransmitters. In addition, theanine can be used as an immunomodulator in animal production. This article reviews the research progress of L-theanine on immunoregulation and related mechanisms, as well as its application in poultry and animal husbandry. It is hoped that this work will be beneficial to future related research.
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页数：14
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